Hypervirulence of a rough variant of the Mycobacterium abscessus type strain

被引：155

作者：

Catherinot, E.

Clarissou, J.

Etienne, G.

Ripoll, F.

Emile, J. -F.

Daffe, M.

Perronne, C.

Soudais, C.

Gaillard, J. -L.

Rottman, M.

机构：

[1] Hop Raymond Poincare, AP HP, Microbiol Lab, F-92380 Garches, France

[2] Hop Raymond Poincare, AP HP, Dept Med Aigue Specialisee, F-92380 Garches, France

[3] Univ Versailles St Quantin, Fac Med Paris, F-92380 Garches, France

[4] CNRS, UMR 5089, Inst Pharmacol Biol Struct, Dept Mecanismes Mol Infect Mycobacteriennes, F-31077 Toulouse, France

[5] Hop Ambroise Pare, AP HP, Lab Anatomopathol, F-92100 Boulogne, France

[6] Hop Necker Enfants Malad, AP HP, Unite Immunol & Hematol, F-75730 Paris 15, France

[7] Univ Paris 05, INSERM, U550, Fac Med Necker Enfants Malad,Lab Human Genet Infe, F-75730 Paris 15, France

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 02期

关键词：

D O I：

10.1128/IAI.00835-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.

引用

页码：1055 / 1058

页数：4

共 27 条

[1] ISOLATION IN HIGH-FREQUENCY OF ROUGH VARIANTS OF MYCOBACTERIUM-INTRACELLULARE LACKING C-MYCOSIDE GLYCOPEPTIDOLIPID ANTIGENS [J].