Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral-induced carcinoma?

被引:555
作者
Nasman, Anders
Attner, Per [2 ]
Hammarstedt, Lalle [2 ]
Do, Juan
Eriksson, Mathilda
Giraud, Geraldine
Ahrlund-Richter, Sofie
Marklund, Linda [2 ]
Romanitan, Mircea
Lindquist, David
Ramqvist, Torbjorn
Lindholm, Johan
Sparen, Par [3 ]
Ye, Weimin [3 ]
Dahistrand, Hanna
Munck-Wikland, Eva [2 ]
Dalianis, Tina [1 ]
机构
[1] Karolinska Univ Hosp, Dept Oncol Pathol, Karolinska Inst, CCK, S-17176 Stockholm, Sweden
[2] Karolinska Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Karolinska Inst, S-17176 Stockholm, Sweden
[3] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden
基金
瑞典研究理事会;
关键词
HPV; tonsillar cancer; oropharyngeal cancer; SQUAMOUS-CELL CARCINOMA; FAVORABLE PROGNOSTIC-FACTOR; UNITED-STATES; ORAL-CAVITY; RISK-FACTOR; OROPHARYNGEAL CANCER; NECK CANCERS; HEAD; PREVALENCE; INFECTION;
D O I
10.1002/ijc.24339
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In the county of Stockholm, between 1970 and 2002, we have previously reported a 3-fold parallel increase in the incidence of tonsillar squamous cell carcinoma (SCC) and the proportion of human papillomavirus (HPV) positive tonsillar SCC. Here, we have followed the above parameters in all patients (n = 120) diagnosed with tonsillar SCC during 2003-2007 in the same area, and also in correlation to our previous data. Ninety-eight pretreatment biopsies were available and presence of HPV DNA and HPV-16 E6 and E7 RNA were tested by polymerase chain reaction (PCR) and RT-PCR. Incidence data were obtained from the Swedish Cancer Registry. Data reported from 1970 to 2002 were also obtained For comparison. HPV DNA was present in 83 of 98 (85%) of the tonsillar SCC biopsies from 2003 to 2007 and 77 of these were HPV-16 positive. HPV-16 E6 and E7 RNA were found in 98% of 52 analyzed HPV-16 positive cases. The proportion of HPV-positive cancers had significantly increased both from 1970 to 2007 (p < 0.0001) as well from 2000 to 2007 (p < 0.01), with 68% (95% confidence interval (CI), 53-81) 2000-2002; 77% (95% CI, 63-87) 2003-2005; and 93% (95% CI, 82-99) 2006-2007. The incidence rate of HPV-positive tumors almost doubled each decade between 1970 and 2007, in parallel with a decline of HPV-negative tumors. In conclusion, the incidence of HPV-positive cancers is still increasing in the County of Stockholm, suggesting an epidemic of a virus-induced carcinoma, with soon practically all tonsillar SCC being HPV positive, as in cervical cancer. (C) 2009 UICC
引用
收藏
页码:362 / 366
页数:5
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