Cancer's deadly signature

被引：49

作者：

Liotta, LA ^{[1
]}

Kohn, EC ^{[1
]}

机构：

[1] NCI, Pathol Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE GENETICS | 2003年 / 33卷 / 01期

关键词：

D O I：

10.1038/ng0103-10

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Theories of cancer biology have long held that the metastatic process originates with rare cells within the primary tumor. A new study using expression array analysis has identified a molecular signature of metastatic potential within the bulk of the primary tumor. This suggests that the majority of tumor cells have the potential to metastasize and presents exciting clinical and therapeutic applications.

引用

页码：10 / 11

页数：2

共 5 条

[1] METASTASIS RESULTS FROM PREEXISTING VARIANT CELLS WITHIN A MALIGNANT-TUMOR
FIDLER, IJ
KRIPKE, ML
[J]. SCIENCE, 1977, 197 (4306) : 893 - 895
[2] KOHN EC, 1995, CANCER RES, V55, P1856
[3] The microenvironment of the tumour-host interface
Liotta, LA
Kohn, EC
[J]. NATURE, 2001, 411 (6835) : 375 - 379
[4] PATHOGENESIS OF CANCER METASTASIS
POSTE, G
FIDLER, IJ
[J]. NATURE, 1980, 283 (5743) : 139 - 146
[5] A molecular signature of metastasis in primary solid tumors
Ramaswamy, S
Ross, KN
Lander, ES
Golub, TR
[J]. NATURE GENETICS, 2003, 33 (01) : 49 - 54

← 1 →