Increased IFN-γ protein in bronchoalveolar lavage fluid of anti-IP-10 antibody-treated F344 rats following Sendai viral infection

被引：6

作者：

Cai, XZ ^{[1
]}

Castleman, WL ^{[1
]}

机构：

[1] Univ Florida, Dept Pathobiol, Gainesville, FL 32611 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2002年 / 22卷 / 12期

关键词：

D O I：

10.1089/10799900260475687

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A previous study showed that virus-resistant F344 rats had higher levels of interferon-gamma (IFN-gamma)-inducible protein 10 (IP-10) than did virus-susceptible BN rats early after Sendai viral infection. The initial goal of this study was to determine if an early high expression of IP-10 in F344 rats contributes to their resistance to virus-induced airway injury. Infected F344 rats were treated with anti-IP-10 rabbit serum or normal rabbit serum. Results indicated that blocking of IP-10 protein did not significantly change the resistance of F344 rats. However, we observed that neutralization of IP-10 increased IFN-gamma protein in bronchoalveolar lavage (BAL) fluid of F344 rats 7 days after inoculation compared with rats that received normal rabbit serum. The pulmonary IFN-gamma mRNA abundance remained comparable. This effect was not caused by fluctuation of the viral titer in the lung. This interesting phenomenon suggests that expression of IFN-gamma protein can be modulated by treatment with anti-IP-10 antibody at the posttranscriptional or translational level in this model.

引用

页码：1175 / 1179

页数：5

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