Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value

被引:384
作者
Yao, Jun-Tao [1 ,2 ]
Zhao, Shu-Hong [3 ]
Liu, Qiu-Ping [4 ,5 ]
Lv, Mo-Qi [5 ]
Zhou, Dang-Xia [5 ,7 ]
Liao, Zi-Jun [6 ]
Nan, Ke-Jun [1 ]
机构
[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Oncol, Xian 710061, Peoples R China
[2] Xi An Jiao Tong Univ, Med Coll,Shaanxi Prov Tumor Hosp, Affiliated Shaanxi Prov Tumor Hosp, Integrated Dept TCM & Western Med, Xian 710061, Peoples R China
[3] Shaanxi Prov Peoples Hosp, Dept Radiat, Xian 710068, Peoples R China
[4] 323 Hosp PLA, Ward VIP 3, Xian 710054, Peoples R China
[5] Xi An Jiao Tong Univ, Med Sch, Dept Pathol, Xian 710061, Peoples R China
[6] Xi An Jiao Tong Univ, Affiliated Shaanxi Prov Tumor Hosp, Med Coll, Dept Internal Med 1, Xian 710061, Peoples R China
[7] Minist Educ, Key Lab Environm & Genes Related Dis, Xian 710061, Peoples R China
关键词
CircRNA_100876; Non-small-cell lung cancer (NSCLC); Biomarker; Prognosis; CIRCULAR RNA; BIOMARKER; CARCINOMA; SURVIVAL; MIR-7;
D O I
10.1016/j.prp.2017.02.011
中图分类号
R36 [病理学];
学科分类号
100103 [病原生物学];
摘要
Circular RNAs (circRNAs) are a novel type of endogenous RNAs featuring stable structure and high tissue specific expression. Recently, accumulating evidence has revealed that aberrant circRNAs expression plays important roles in carcinogenesis and tumor progression. However, the expression pattern and biological function of circRNAs in non small cell lung cancer (NSCLC) remain largely unknown. Therefore, the purpose of this study was to clarify the possible role of one of typical circRNAs, circRNA_100876 in NSCLC and to define its prognostic value in NSCLC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of circRNA_100876 in tumor tissues and their adjacent nontumorous tissues in 101 patients with NSCLC. We found that the expression level of circRNA_100876 was significantly elevated in NSCLC tissues when compared with their adjacent nontumorous tissues (P = 0.000). Moreover, there was a close correlation between the circRNA_100876 up-regulation expression and lymph node metastasis (P = 0.001) and tumor staging (P = 0.001) in NSCLC. In addition, Kaplan-Meier survival analysis demonstrated that the overall survival time of NSCLC patients with high circRNA_100876 expression was significantly shorter than those patients with low circRNA_100876 expression (P = 0.000). In conclusion, our findings indicate that circRNA_100876 is closely related to the carcinogenesis of NSCLC and it might be served as a potential prognostic biomarker and therapeutic target for NSCLC. (C) 2017 Elsevier GmbH. All rights reserved.
引用
收藏
页码:453 / 456
页数:4
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