Activation of NADPH oxidase in Alzheimer's disease brains

被引：252

作者：

Shimohama, S ^{[1
]}

Tanino, H

Kawakami, N

Okamura, N

Kodama, H

Yamaguchi, T

Hayakawa, T

Nunomura, A

Chiba, S

Perry, G

Smith, MA

Fujimoto, S

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto 6068507, Japan

[2] Kyoto Pharmaceut Univ, Dept Environm Biochem, Kyoto 6078414, Japan

[3] Hiroshima Univ, Sch Med, Dept Physiol Chem, Hiroshima 7348551, Japan

[4] Natl Inst Hlth Sci, Div Biol Chem, Tokyo 1588501, Japan

[5] Asahikawa Med Coll, Dept Psychiat & Neurol, Asahikawa, Hokkaido 0788510, Japan

[6] Case Western Reserve Univ, Inst Pathol, Cleveland, OH 44106 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 273卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; NADPH oxidase; p47-phox; p67-phox; amyloid beta; translocation; superoxide; microglia;

D O I：

10.1006/bbrc.2000.2897

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study is the first to show that superoxide (O-2(-)) forming NADPH oxidase is activated in Alzheimer's disease (AD) brains by demonstrating the marked translocation of the cytosolic factors p47-phox and p67-phox to the membrane. In conjunction with a recent in vitro study showing that amyloid beta activates O-2(-) forming NADPH oxidase in microglia, where these phox proteins are localized in this study, the present results suggest that, in AD, NADPH oxidase is activated in microglia, resulting in the formation of reactive oxygen species which can be toxic to neighboring neurons in AD. (C) 2000 Academic Press.

引用

页码：5 / 9

页数：5

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