The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system

被引：145

作者：

Hartung, HP ^{[1
]}

Kieseier, BC ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Dept Neurol, A-8036 Graz, Austria

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 107卷 / 02期

关键词：

matrix metalloproteinases; inflammatory demyelination; Multiple sclerosis; Guillain-Barre syndrome;

D O I：

10.1016/S0165-5728(00)00225-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Members of the family of matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of inflammatory demyelination. MMPs apparently mediate Important steps in the genesis of inflammatory demyelination, such as cell migration, blood-brain/nerve barrier breakdown, demyelination. and cytokine activation. This review will highlight in vitro as well as in vivo findings, which support the importance of this group of proteases in the pathogenesis of inflammatory demyelinating disorders of the central and peripheral nervous system. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：140 / 147

页数：8

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