Langerhans cell tropism of human immunodeficiency virus type 1 subtype A through F isolates derived from different transmission groups

被引：79

作者：

Dittmar, MT

Simmons, G

Hibbitts, S

OHare, M

Louisirirotchanakul, S

Beddows, S

Weber, J

Clapham, PR

Weiss, RA

机构：

[1] UCL, LUDWIG INST CANC RES, BREAST CANC LAB, LONDON W1, ENGLAND

[2] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, ST MARYS HOSP, SCH MED, LONDON W2 1PG, ENGLAND

来源：

JOURNAL OF VIROLOGY | 1997年 / 71卷 / 10期

关键词：

D O I：

10.1128/JVI.71.10.8008-8013.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学]; 100705 [微生物与生化药学];

摘要：

To test the hypothesis that some subtypes of human immunodeficiency virus type 1 (HIV-1), especially subtype E, are more likely to infect mature Langerhans cells (mLC), we titrated a panel of 26 primary HIV-1 isolates of subtypes A through F on peripheral blood mononuclear cells (PBMC) and mLC, The majority of HIV-1 isolates from heterosexually infected patients did not show a preferred tropism for mLC compared to homosexually transmitted HIV-1 isolates, Only 6 of 26 isolates, 2 from patients infected by homosexual contact and 1 from patients infected by heterosexual contact, showed a higher infectivity for mLC than far PBMC. Both syncytium-inducing and non-syncytium-inducing isolates were able to infect mLC which express mRNA for the chemokine receptors CCR3, CCR5, and CXCR4.

引用

页码：8008 / 8013

页数：6

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