Immunopathogenesis of hepatitis B virus infection

被引：148

作者：

Chang, J. Judy

Lewin, Sharon R.

机构：

[1] Alfred Hosp, Infect Dis Unit, Melbourne, Vic 3004, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[3] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2007年 / 85卷 / 01期

关键词：

cirrhosis; hepatitis B virus; immunology; immunopathogenesis; innate immunity; T-cells;

D O I：

10.1038/sj.icb.7100009

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Hepatitis B virus (HBV) infection is a non-cytopathic hepatotropic virus that can lead to severe liver disease including acute hepatitis, cirrhosis and hepatocellular carcinoma. Successful clearance of the virus as well as the establishment of liver disease is largely driven by a complex interaction between the virus and the host immune response. In this review, the immunological events, including both the innate and adaptive immune response are discussed in the setting of both acute and chronic HBV infection and liver disease.

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页码：16 / 23

页数：8

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