A new method for the formation of 2,4-disubstituted oxazoles: internal transfer of oxidation state through a molecular framework

被引：20

作者：

Cardwell, KS ^{[1
]}

Hermitage, SA ^{[1
]}

Sjolin, A ^{[1
]}

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Chem Dev Div, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 21期

关键词：

oxazoline; oxazole; oxidation;

D O I：

10.1016/S0040-4039(00)00573-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of 2,4-disubstituted oxazoles is described from readily available starting materials. The synthesis avoids the necessity for the oxidation of an oxazoline to an oxazole by utilising an internal transfer of oxidation state across a molecular framework and has been performed on multigram scale. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4239 / 4242

页数：4

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