Histone methyltransferases, diet nutrients and tumour suppressors

被引：118

作者：

Huang, S ^{[1
]}

机构：

[1] Burnham Inst, Canc Res Ctr, Program Oncogenes & Tumor Suppressor Genes, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期

关键词：

D O I：

10.1038/nrc819

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is well known that an insufficiency of dietary methyl-group donors can cause cancer, and that a deficiency in methylation is characteristic of cancer, but how carcinogenesis results from abnormal methyl-donor metabolism has long remained a matter of speculation. Recently, however, it has been found that some histone methyltransferases, which require methyl donors for activity, are tumour suppressors.

引用

页码：469 / 476

页数：8

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