Lac repressor genetic map in real space

被引：52

作者：

Pace, HC

Kercher, MA

Lu, P

Markiewicz, P

Miller, JH

Chang, G

Lewis, M

机构：

[1] UNIV CALIF LOS ANGELES,INST MOL BIOL,DEPT MICROBIOL & MOL GENET,LOS ANGELES,CA 90024

[2] UNIV PENN,DEPT BIOCHEM & BIOPHYS,JOHNSON RES FDN,PHILADELPHIA,PA 19104

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(97)01104-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we present a graphic display of the phenotypes of more than 4000 single amino acid substitution mutations on the three-dimensional structure of the lac repressor tetramer bound to DNA. The genetic data and the X-ray diffraction studies contribute to define an allosteric mechanism and yield a visual demonstration of the importance of core or buried residues in protein structure.

引用

收藏

页码：334 / 339

页数：6

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