Epigenetics and cancer

被引：366

作者：

Lund, AH

van Lohuizen, M

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

[2] Biotech Res & Innovat Ctr, DK-2100 Copenhagen, Denmark

来源：

GENES & DEVELOPMENT | 2004年 / 18卷 / 19期

关键词：

epigenetics; cancer; chromatin; histone code; polycomb; SET domain proteins;

D O I：

10.1101/gad.1232504

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional regulation locally and globally via modifications of the DNA and by modification or rearrangement of nucleosomes. Epigenetic gene regulation collaborates with genetic alterations in cancer development. This is evident from every aspect of tumor biology including cell growth and differentiation, cell cycle control, DNA repair, angiogenesis, migration, and evasion of host immunosurveillance. In contrast to genetic cancer causes, the possibility of reversing epigenetic codes may provide new targets for therapeutic intervention.

引用

收藏

页码：2315 / 2335

页数：21

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