Iron-catalysed Suzuki coupling? A cautionary tale

被引：53

作者：

Bedford, Robin B. ^{[1
]}

Nakamura, Masaharu ^{[2
]}

Gower, Nicholas J. ^{[1
]}

Haddow, Mairi F. ^{[1
]}

Hall, Mark A. ^{[1
]}

Huwe, Michael ^{[1
]}

Hashimoto, Tohru ^{[2
,3
]}

Okopie, Rukeme A. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] Kyoto Univ, Inst Chem Res, Int Res Ctr Elements Sci, Uji 6110011, Japan

[3] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Nishikyo Ku, Kyoto 6158510, Japan

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 45期

基金：

英国工程与自然科学研究理事会;

关键词：

Iron catalysts; Pyridine ligands; Suzuki cross-coupling; Biaryls; PHOSPHINITE COMPLEXES; ORGANIC-SYNTHESIS; TRANS-TETRAKIS(PYRIDINE)DICHLOROIRON(II);

D O I：

10.1016/j.tetlet.2009.08.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In our hands, Fe(II) or (III) pyridine complexes show no activity in Suzuki biaryl cross-coupling reactions, except in one irreproducible instance when complete conversion was observed. A comparison with palladium acetate under the same conditions showed that complete conversion can be obtained in a S:C ratio of 1,000,000:1 and therefore extreme caution must be exercised to prevent 'false-positives' arising from trace Pd-contaminants. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6110 / 6111

页数：2

共 16 条

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