PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

被引：537

作者：

Srinivasan, Lakshmi ^{[1
,2
]}

Sasaki, Yoshiteru ^{[1
,2
]}

Calado, Dinis Pedro ^{[1
,2
]}

Zhang, Baochun ^{[1
,2
]}

Paik, Ji Hye ^{[3
]}

DePinho, Ronald A. ^{[3
]}

Kutok, Jeffrey L. ^{[4
]}

Kearney, John F. ^{[5
]}

Otipoby, Kevin L. ^{[1
,2
]}

Rajewsky, Klaus ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Immune Dis Inst, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[5] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

CELL | 2009年 / 139卷 / 03期

关键词：

NF-KAPPA-B; FOXO TRANSCRIPTION FACTORS; CLASS-SWITCH RECOMBINATION; ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL; 3-KINASE; MARGINAL ZONE; POSITIVE SELECTION; CRITICAL ROLES; LYMPHOCYTES; ACTIVATION;

D O I：

10.1016/j.cell.2009.08.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role.

引用

页码：573 / 586

页数：14

共 58 条

[1] Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase [J].