Palmitoylation-dependent protein sorting

被引：203

作者：

Greaves, Jennifer ^{[1
]}

Chamberlain, Luke H. ^{[1
]}

机构：

[1] Univ Glasgow, Fac Biomed & Life Sci, Div Biochem & Mol Biol, Henry Wellcome Lab Cell Biol, Glasgow G12 8QQ, Lanark, Scotland

来源：

JOURNAL OF CELL BIOLOGY | 2007年 / 176卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

H-RAS; PALMITATE TURNOVER; FATTY ACYLATION; MODEL MEMBRANES; GOLGI-COMPLEX; TRAFFICKING; PEPTIDES; CHOLESTEROL; PSD-95; LOCALIZATION;

D O I：

10.1083/jcb.200610151

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

S-palmitoylation is a posttranslational modi. cation that regulates membrane-protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various aspects of protein sorting within the cell.

引用

收藏

页码：249 / 254

页数：6

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