Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis

被引：108

作者：

Drake, Wonder P.

Dhason, Mary S.

Nadaf, Michele

Shepherd, Bryan E.

Vadivelu, Sangeetha

Hajizadeh, Rana

Newman, Lee S.

Kalams, Spyros A.

机构：

[1] Vanderbilt Univ, Sch Med, Div Infect Dis, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Biostat, Nashville, TN 37232 USA

[4] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA

[5] Univ Colorado Denver & Hlth Sci Ctr, Dept Med, Denver, CO USA

[6] Univ Colorado Denver & Hlth Sci Ctr, Dept Prevent Med & Biometr, Denver, CO USA

来源：

INFECTION AND IMMUNITY | 2007年 / 75卷 / 01期

关键词：

D O I：

10.1128/IAI.00732-06

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.

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收藏

页码：527 / 530

页数：4

相关论文

共 16 条

[1] Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif [J].

Altfeld, MA ;

Livingston, B ;

Reshamwala, N ;

Nguyen, PT ;

Addo, MM ;

Shea, A ;

Newman, M ;

Fikes, J ;

Sidney, J ;

Wentworth, P ;

Chesnut, R ;

Eldridge, RL ;

Rosenberg, ES ;

Robbins, GK ;

Brander, C ;

Sax, PE ;

Boswell, S ;

Flynn, T ;

Buchbinder, S ;

Goulder, PJR ;

Walker, BD ;

Sette, A ;

Kalams, SA .

JOURNAL OF VIROLOGY, 2001, 75 (03) :1301-1311

[2] Comparative genomics of BCG vaccines by whole-genome DNA microarray [J].

Behr, MA ;

Wilson, MA ;

Gill, WP ;

Salamon, H ;

Schoolnik, GK ;

Rane, S ;

Small, PM .

SCIENCE, 1999, 284 (5419) :1520-1523

[3] Molecular analysis of sarcoidosis tissues for Mycobacterium species DNA [J].

Drake, WP ;

Pei, ZH ;

Pride, DT ;

Collins, RD ;

Cover, TL ;

Blaser, MJ .

EMERGING INFECTIOUS DISEASES, 2002, 8 (11) :1334-1341

[4] Serum anti-mycobacteria heat shock proteins antibodies in sarcoidosis and tuberculosis [J].

Dubaniewicz, A ;

Kämpfer, S ;

Singh, M .

TUBERCULOSIS, 2006, 86 (01) :60-67

[5] Mycobacterium tuberculosis complex and mycobacterial heat shock proteins in lymph node tissue from patients with pulmonary sarcoidosis [J].

Dubaniewicz, Anna ;

Dubaniewicz-Wybieralska, Miroslawa ;

Sternau, Adam ;

Zwolska, Zofia ;

Izycka-Swieszewska, Ewa ;

Augustynowicz-Kopec, Ewa ;

Skokowski, Jaroslaw ;

Singh, Mahavir ;

Zimnoch, Lech .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (09) :3448-3451

[6]

FOLEY N, 1990, CLIN EXP IMMUNOL, V80, P395

[7] CHARACTERIZATION OF THE KATG GENE ENCODING A CATALASE-PEROXIDASE REQUIRED FOR THE ISONIAZID SUSCEPTIBILITY OF MYCOBACTERIUM-TUBERCULOSIS [J].

HEYM, B ;

ZHANG, Y ;

POULET, S ;

YOUNG, D ;

COLE, ST .

JOURNAL OF BACTERIOLOGY, 1993, 175 (13) :4255-4259

[8] SARCOIDOSIS - HISTOPATHOLOGICAL DEFINITION AND CLINICAL DIAGNOSIS [J].

MITCHELL, DN ;

SCADDING, JG ;

HEARD, BE ;

HINSON, KFW .

JOURNAL OF CLINICAL PATHOLOGY, 1977, 30 (05) :395-408

[9] Medical progress - Sarcoidosis [J].

Newman, LS ;

Rose, CS ;

Maier, LA .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (17) :1224-1234

[10]

Pathan AA, 2000, EUR J IMMUNOL, V30, P2713, DOI 10.1002/1521-4141(200009)30:9<2713::AID-IMMU2713>3.0.CO