To do or not to do: IVF and ICSI in chronic hepatitis B virus carriers

被引：22

作者：

Lutgens, Suzanne P. M. ^{[2
]}

Nelissen, Ewka C. M. ^{[1
]}

van Loo, Inge H. M. ^{[2
]}

Koek, Ger H. ^{[3
]}

Derhaag, Josien G. ^{[1
]}

Dunselman, Gerard A. J. ^{[1
]}

机构：

[1] Maastricht Univ, Med Ctr, Res Inst Growth & Dev GROW, Dept Obstet & Gynaecol, NL-6202 AZ Maastricht, Netherlands

[2] Maastricht Univ, Med Ctr, Res Inst Growth & Dev GROW, Dept Med Microbiol, NL-6202 AZ Maastricht, Netherlands

[3] Maastricht Univ, Med Ctr, Res Inst Growth & Dev GROW, Dept Internal Med,Div Gastroenterol & Hepatol, NL-6202 AZ Maastricht, Netherlands

来源：

HUMAN REPRODUCTION | 2009年 / 24卷 / 11期

关键词：

hepatitis B; IVF; ICSI; quality control; vertical transmission; HUMAN SPERM CHROMOSOMES; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTION; HBV DNA; EXPRESSION; INFECTION; OOCYTES; GENOME;

D O I：

10.1093/humrep/dep258

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Several assisted reproduction procedures, such as IVF and ICSI, are available for a variety of infertility problems. In fertility clinics, patients are screened for blood-borne viral infections, including hepatitis B virus (HBV). Reasons for screening are prevention of vertical transmission and laboratory safety. We present the case of a 26-year-old female patient with a chronic HBV infection, whose husband tested negative for hepatitis B. She and her husband were referred to our fertility clinic because of subfertility. Analysis of the husband's semen indicated the necessity of an ICSI procedure. The current Dutch guidelines advise against ICSI in chronic HBV carriers, since the risks and effects of chromosomal integration of HBV DNA in the fetus are not well-known. In this article, we review the scientific evidence for the risk of introducing HBV virus into the oocyte and subsequent integration of HBV DNA into the human genome, and debate the question of whether to do, or not to do, IVF and ICSI.

引用

页码：2676 / 2678

页数：3

共 13 条

[1]

Expression of hepatitis B virus genes in early embryonic cells originated from hamster ova and human spermatozoa transfected with the complete viral genome [J].