Mediators on human airway smooth muscle

被引：10

作者：

Armour, C ^{[1
]}

Johnson, P ^{[1
]}

Anticevich, S ^{[1
]}

Ammit, A ^{[1
]}

McKay, K ^{[1
]}

Hugh, M ^{[1
]}

Black, J ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT PHARM,RESP RES GRP,SYDNEY,NSW 2006,AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1997年 / 24卷 / 3-4期

关键词：

airway muscle; atopy; human airway; mast cells; mediators; muscle growth; sensitization; smooth muscle; BRONCHIAL HYPERRESPONSIVENESS; NEUROKININ-A; INVITRO; RESPONSIVENESS; SENSITIZATION; HISTAMINE; METHACHOLINE; REACTIVITY; RESPONSES; ASTHMA;

D O I：

10.1111/j.1440-1681.1997.tb01818.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. Bronchial hyperresponsiveness in asthma may be due to several abnormalities, but must include alterations in the airway smooth muscle responsiveness and/or volume. 2. Increased responsiveness of airway smooth muscle in vitro can be induced by certain inflammatory cell products and by induction of sensitization (atopy). 3. Increased airway smooth muscle growth can also be induced by inflammatory cell products and atopic serum. 4. Mast cell numbers are increased in the airways of asthmatics and, in our studies, in airway smooth muscle that is sensitized and hyperresponsive. 5. We propose that there is a relationship between mast cells and airway smooth muscle cells which, once an allergic process has been initiated, results in the development of critical features in the lungs in asthma.

引用

页码：269 / 272

页数：4

共 32 条

[1] INDUCTION OF HUMAN AIRWAY HYPERRESPONSIVENESS BY TUMOR-NECROSIS-FACTOR-ALPHA [J].