t(19;22)(q13;q12) Translocation Leading to the Novel Fusion Gene EWSRI-ZNF444 in Soft Tissue Myoepithelial Carcinoma

被引：94

作者：

Brandal, Petter ^{[1
,2
]}

Panagopoulos, Ioannis ^{[3
]}

Bjerkehagen, Bodil ^{[4
]}

Heim, Sverre ^{[2
,5
]}

机构：

[1] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Oncol, Div Canc Med & Radiotherapy, Oslo, Norway

[2] Oslo Univ Hosp, Norwegian Radium Hosp, Dept Med Genet, Div Lab Med, Oslo, Norway

[3] Lund Univ, Dept Clin Genet, Lund, Sweden

[4] Oslo Univ Hosp, Norwegian Radium Hosp, Div Pathol, Oslo, Norway

[5] Univ Oslo, Fac Med, N-0316 Oslo, Norway

来源：

GENES CHROMOSOMES & CANCER | 2009年 / 48卷 / 12期

基金：

瑞典研究理事会;

关键词：

MALIGNANT MYOEPITHELIOMA; TUMORS;

D O I：

10.1002/gcc.20706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myoepithelial neoplasms of soft tissue have only recently been acknowledged as a separate diagnostic entity. To know based on histological appearance whether these tumors are benign or malignant is often difficult, and their tumorigenic mechanisms remain poorly understood. We report a myoepithelial carcinoma with an aberrant near-diploid karyotype, 43 similar to 47,XX,add(1)(p34)x2,add(3)(q27)x2,del(12)(q22),+add(18)(p11)x2,del(22)(q11),+r, found in cells cultured from a lung metastasis. The deletion in 22q led us to search by molecular cytogenetic means for possible EWSRI rearrangements, and eventually a novel chimeric gene consisting of the 5'-end of EWSRI (22q12) and the 3'-end of ZNF444 (19q13) was found. How the new fusion gene contributes to tumorigenesis is unknown, but the finding of an EWSRI rearrangement suggests that this, possibly even the EWSRI-ZNF444, is a defining pathogenetic feature of at least a subset of these tumors. (C) 2009 Wiley-Liss, Inc.

引用

页码：1051 / 1056

页数：6

共 16 条

[1] FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities [J].