Obesity therapy: Altering the energy intake-and- expenditure balance sheet

被引：96

作者：

Crowley, VEE

Yeo, GSH

O'Rahilly, S ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Cambridge CB2 2QR, England

[2] Univ Cambridge, Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QR, England

[3] Addenbrookes Hosp, Cambridge Inst Med Res, Cambridge CB2 2XY, England

来源：

NATURE REVIEWS DRUG DISCOVERY | 2002年 / 1卷 / 04期

关键词：

D O I：

10.1038/nrd770

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Obesity is associated with numerous health complications, which range from non-fatal debilitating conditions such as osteoarthritis, to life-threatening chronic diseases such as coronary heart disease, diabetes and certain cancers. The psychological consequences of obesity can range from lowered self-esteem to clinical depression. Despite the high prevalence of obesity and the many advances in our understanding of how it develops, current therapies have persistently failed to achieve long-term success. This review focuses on how fat mass can be reduced by altering the balance between energy intake and expenditure.

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页码：276 / 286

页数：11

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