Metabotropic glutamate receptor 4 interacts with microtubule-associated protein 1B

被引：15

作者：

Moritz, Anina ^{[1
]}

Scheschonka, Astrid ^{[1
]}

Beckhaus, Tobias ^{[2
]}

Karas, Michael ^{[2
]}

Betz, Heinrich ^{[1
]}

机构：

[1] Max Planck Inst Brain Res, Dept Neurochem, D-60528 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Inst Pharmaceut Chem, D-60438 Frankfurt, Germany

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 390卷 / 01期

关键词：

Metabotropic glutamate receptor 4; Microtubule-associated protein 1B; Protein interaction; NERVOUS-SYSTEM; MICE LACKING; BINDING; CALMODULIN; MGLUR4; PICK1; MODULATION; ACTIVATION; SEIZURES; MAP1B;

D O I：

10.1016/j.bbrc.2009.09.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The metabotropic glutamate receptor 4 (mGluR4) is a G-protein-coupled receptor that mediates inhibition of neurotransmitter release. Here, we used a proteomic approach to identify novel interaction partners of mGluR4 and report that the cytoplasmic C-terminal tail of mGluR4 interacts with microtubule-associated protein 1B (MAP1B). Binding of MAP1B to mGluR4 is inhibited by Ca2+/calmodulin, and MAP1B and mGluR4 colocalize at excitatory synapses in cultured hippocampal neurons. Thus, MAP1B might be implicated in the synaptic trafficking and/or regulation of mGluR4. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：82 / 86

页数：5

共 31 条

[1]

Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival [J].

Allen, E ;

Ding, JQ ;

Wang, W ;

Pramanik, S ;

Chou, J ;

Yau, V ;

Yang, YM .

NATURE, 2005, 438 (7065) :224-228

[2]

Pharmacological activation of mGlu4 metabotropic glutamate receptors reduces nigrostriatal degeneration in mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [J].

Battaglia, Giuseppe ;

Busceti, Carla L. ;

Molinaro, Gemma ;

Biagioni, Francesca ;

Traficante, Anna ;

Nicoletti, Ferdinando ;

Bruno, Valeria .

JOURNAL OF NEUROSCIENCE, 2006, 26 (27) :7222-7229

[3]

PICK1 uncoupling from mGluR7a causes absence-like seizures [J].

Bertaso, Federica ;

Zhang, Chuansheng ;

Scheschonka, Astrid ;

de Bock, Frederic ;

Fontanaud, Pierre ;

Marin, Philippe ;

Huganir, Richard L. ;

Betz, Heinrich ;

Bockaert, Joeal ;

Fagni, Laurent ;

Lerner-Natoli, Mireille .

NATURE NEUROSCIENCE, 2008, 11 (08) :940-948

[4]

Selective activation of mGlu4 metabotropic glutamate receptors is protective against excitotoxic neuronal death [J].

Bruno, V ;

Battaglia, G ;

Ksiazek, I ;

van der Putten, H ;

Catania, MV ;

Giuffrida, R ;

Lukic, S ;

Leonhardt, T ;

Inderbitzin, W ;

Gasparini, F ;

Kuhn, R ;

Hampson, DR ;

Nicoletti, F ;

Flor, PJ .

JOURNAL OF NEUROSCIENCE, 2000, 20 (17) :6413-6420

[5]

Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7 [J].

Caldwell, John H. ;

Herin, Greta Ann ;

Nagel, Georg ;

Bamberg, Ernst ;

Scheschonka, Astrid ;

Betz, Heinrich .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (36) :24300-24307

[6]

Pharmacology and functions of metabotropic glutamate receptors [J].

Conn, PJ ;

Pin, JP .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :205-237

[7]

Microtubule-associated protein 1B binds glyceraldehyde-3-phosphate dehydrogenase [J].

Cueille, Nathalie ;

Blanc, Corinne Tallichet ;

Riederer, Irene M. ;

Riederer, Beat M. .

JOURNAL OF PROTEOME RESEARCH, 2007, 6 (07) :2640-2647

[8]

Characterization of the role of microtubule-associated protein 1B in metabotropic glutamate receptor-mediated endocytosis of AMPA receptors in hippocampus [J].

Davidkova, Genoveva ;

Carroll, Reed C. .

JOURNAL OF NEUROSCIENCE, 2007, 27 (48) :13273-13278

[9]

Mapping of calmodulin and Gβγ binding domains within the C-terminal region of the metabotropic glutamate receptor 7A [J].

El Far, O ;

Bofill-Cardona, E ;

Airas, JM ;

O'Connor, V ;

Boehm, S ;

Freissmuth, M ;

Nanoff, C ;

Betz, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (33) :30662-30669

[10]

Identification and functional roles of metabotropic glutamate receptor-interacting proteins [J].

Fagni, L ;

Ango, F ;

Perroy, J ;

Bockaert, J .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2004, 15 (03) :289-298

← 1 2 3 4 →