The genetic program of hematopoietic stem cells

被引：311

作者：

Phillips, RL

Ernst, RE

Brunk, B

Ivanova, N

Mahan, MA

Deanehan, JK

Moore, KA

Overton, GC

Lemischka, IR ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[2] Univ Penn, Computat Biol & Informat Lab, Philadelphia, PA 19104 USA

来源：

SCIENCE | 2000年 / 288卷 / 5471期

关键词：

D O I：

10.1126/science.288.5471.1635

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Blood cell production originates from a rare population of multipotent, self-renewing stem cells. A genome-wide gene expression analysis was performed in order to define regulatory pathways in stem cells as well as their global genetic program. Subtracted complementary DNA Libraries from highly purified murine fetal liver stem cells were analyzed with bioinformatic and array hybridization strategies. A large percentage of the several thousand gene products that have been characterized correspond to previously undescribed molecules with properties suggestive of regulatory functions. The complete data, available in a biological process-oriented database, represent the molecular phenotype of the hematopoietic stem cell.

引用

页码：1635 / 1640

页数：6

共 29 条

[1] Exploring the new world of the genome with DNA microarrays [J].