Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia

被引：18

作者：

Takeuchi, S ^{[1
]}

Takeuchi, N

Tsukasaki, K

Bartram, CR

Zimmermann, M

Schrappe, M

Taguchi, H

Koeffler, HP

机构：

[1] Kochi Med Sch, Dept Med, Nanko Ku, Kochi 7838505, Japan

[2] Univ Calif Los Angeles, Sch Med, Cedars Sinai Res Inst, Div Hematol Oncol, Los Angeles, CA USA

[3] Heidelberg Univ, Inst Human Genet, Heidelberg, Germany

[4] Hannover Med Sch, Dept Pediat Hematol & Oncol, D-3000 Hannover, Germany

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2002年 / 119卷 / 04期

关键词：

tumour necrosis factor; lymphotoxin-alpha; acute lymphoblastic leukaemia; polymorphism; molecular epidemiology;

D O I：

10.1046/j.1365-2141.2002.03964.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic polymorphisms in the tumour necrosis factor (TNF) locus influence the outcome of non-Hodgkin's lymphoma (NHL). We investigated whether these polymorphisms might contribute to the clinical course of childhood acute lymphoblastic leukaemia (ALL). Genomic DNA from 214 childhood ALL patients was analysed. Patients with a high-risk haplotype were older than patients with low-risk haplotype (P = 0.024). No statistically significant associations were found between TNF haplotype and sex, WBC counts, central nervous system involvement, immunophenotype, response to chemotherapy, and event-free survival. These data suggest that genetic polymorphisms in the TNF locus have a limited effect on the outcome of childhood ALL.

引用

页码：985 / 987

页数：3

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