The updated European Consensus 2009 on the use of Botulinum toxin for children with cerebral palsy

被引：192

作者：

Heinen, Florian ^{[1
]}

Desloovere, Kaat ^{[2
]}

Schroeder, A. Sebastian ^{[1
]}

Berweck, Steffen ^{[3
]}

Borggraefe, Ingo ^{[1
]}

van Campenhout, Anya ^{[4
]}

Andersen, Guro L. ^{[5
]}

Aydin, Resa ^{[6
]}

Becher, Jules G. ^{[7
]}

Bernert, Guenther ^{[8
]}

Martinez Caballero, Ignacio ^{[9
]}

Carr, Lucinda ^{[10
]}

Valayer, Emmanuelle Chaleat ^{[11
]}

Desiato, Maria Teresa ^{[12
]}

Fairhurst, Charlie ^{[13
]}

Filipetti, Paul

Hassink, Ralph-Ingo ^{[14
]}

Hustedt, Ulf ^{[15
]}

Jozwiak, Marek ^{[16
]}

Kocer, Serdar Ibrahim ^{[17
]}

Kolanowski, Elisabeth ^{[18
]}

Kraegeloh-Mann, Ingeborg ^{[19
]}

Kutlay, Sehim ^{[20
]}

Maenpaa, Helena ^{[21
]}

Mall, Volker ^{[22
]}

McArthur, Paul ^{[23
]}

Morel, Edith ^{[11
]}

Papavassiliou, Antigone ^{[24
]}

Pascual-Pascual, Ignacio ^{[25
]}

Pedersen, Soren Anker ^{[26
]}

Plasschaert, Frank S. ^{[27
]}

van der Ploeg, Irene ^{[28
]}

Remy-Neris, Olivier ^{[29
]}

Renders, Anne ^{[30
]}

Di Rosa, Guiseppe ^{[31
]}

Steinlin, Maja ^{[32
]}

Tedroff, Kristina ^{[33
,34
]}

Vidal Valls, Joan ^{[35
]}

Viehweger, Elke ^{[36
,37
]}

Molenaers, Guy ^{[4
]}

机构：

[1] Univ Munich, Dr von Hauners Childrens Hosp, Dept Paediat Neurol & Dev Med, D-80337 Munich, Germany

[2] Univ Hosp Pellenberg, Dept Rehabil Sci KUL, Pellenberg, Belgium

[3] Epilepsy Ctr Children & Adolescents, Specialist Ctr Paediat Neurol, D-83569 Vogtareuth, Germany

[4] Univ Hosp Pellenberg, Dept Orthopaed KUL, Pellenberg, Belgium

[5] SiV HF, Habilitat Ctr, N-3103 Tonsberg, Norway

[6] Istanbul Univ, Istanbul Fac Med, Dept Phys Med & Rehabil, Istanbul, Turkey

[7] Vrije Univ Amsterdam Med Ctr, Dept Rehabil Med, NL-1007 MB Amsterdam, Netherlands

[8] Gottfried von Preyersches Kinderspital Stadt Wien, Vienna, Austria

[9] Univ Autonoma Madrid, Hosp Infantil Univ Nino Jesus, Dept Pediat Orthopaed, E-28049 Madrid, Spain

[10] Great Ormond St Hosp Sick Children, Dept Neurol, London WC1N 3JH, England

[11] Ctr Med Chirurg & Readaptat Massues, Lyon, France

[12] S Eugenio Hosp, ASL RMC, Dept Neurophysiopathol, Rome, Italy

[13] Guys & St Thomas Hosp, London SE1 9RT, England

[14] Zentrum Entwicklungsforderung & Padiatr Neuroreha, CH-2502 Biel, Switzerland

[15] Hosp City Frankfurt, Dept Social Paediat, D-65929 Frankfurt, Germany

[16] K Marcinkowski Med Univ, Dept Pediat Othoped & Traumatol, PL-61545 Poznan, Poland

[17] Ctr Med Phys Reeduc, Coubert, France

[18] Ctr Reeduc Fonct Marc Sautelet APF, Villeneuve Dascq, France

[19] Univ Tubingen, Childrens Hosp, Dept Paediat Neurol & Dev Neurol, D-72074 Tubingen, Germany

[20] Ankara Univ, Fac Med, Dept Phys Med & Rehabil, TR-06100 Ankara, Turkey

[21] Univ Hosp Children & Adolescents Helsinki, Rehabil Unit Neurol, Helsinki 00029, Finland

[22] Univ Hosp Freiburg, Dept Pediat & Adolescent Med, Div Neuropediat & Muscular Disorders, Freiburg, Germany

[23] Alder Hey Childrens Hosp, Dept Congenital Hand & Upper Limb Surg, Liverpool L12 2AP, Merseyside, England

[24] Pendeli Childrens Hosp, Dept Neurol, Athens, Greece

[25] Univ Autonoma Madrid, Hosp Infantil La Paz, Dept Child Neurol, E-28049 Madrid, Spain

[26] Hvidovre Univ Hosp, Dept Pediat 460, DK-2650 Hvidovre, Denmark

[27] Ghent Univ Hosp, Dept Orthopaed Surg, B-9000 Ghent, Belgium

[28] Univ Hosp Coventry & Warwickshire, Off ABR 10065, Coventry CV2 2DX, W Midlands, England

[29] CHU Brest, Serv Med Phys & Readaptat, F-29285 Brest, France

[30] Clin Univ St Luc, B-1200 Brussels, Belgium

[31] Osped Pediat Bambino Gesu, Rome, Italy

[32] Inselspital Bern, CH-3010 Bern, Switzerland

[33] Karolinska Inst, Dept Woman & Child Hlth, Astrid Lindgren Childrens Hosp, Neuropediat Unit, S-10401 Stockholm, Sweden

[34] Stockholm Brain Inst, Stockholm, Sweden

[35] ASPACE Barcelona, Ctr Pilot Arcangel St Gabriel, Barcelona 08038, Spain

[36] Hop Enfants La Timone, Serv Orthoped Pediat, Marseille, France

[37] Univ Mediterranee, Fac Med, Marseille, France

来源：

EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY | 2010年 / 14卷 / 01期

关键词：

Botulinum toxin; Cerebral palsy; GROSS MOTOR FUNCTION; ABILITY CLASSIFICATION-SYSTEM; INTRATHECAL BACLOFEN THERAPY; A NEUROMUSCULAR BLOCKADE; MANUAL NEEDLE PLACEMENT; UPPER-LIMB MOVEMENT; DOUBLE-BLIND; GASTROCNEMIUS-MUSCLE; NITROUS-OXIDE; LOWER-EXTREMITY;

D O I：

10.1016/j.ejpn.2009.09.005

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

An interdisciplinary European group of clinical experts in the field of movement disorders and experienced Botulinum toxin users has updated the consensus for the use of Botulinum toxin in the treatment of children with cerebral palsy (CP). A problem-orientated approach was used focussing on both published and practice-based evidence. In part I of the consensus the authors have tabulated the supporting evidence to produce a concise but comprehensive information base, pooling data and experience from 36 institutions in 9 European countries which involves more than 10,000 patients and over 45,000 treatment sessions during a period of more than 280 treatment years. In part II of the consensus the Gross Motor Function Measure (GMFM) and Gross Motor Function Classification System (GMFCS) based Motor Development Curves have been expanded to provide a graphical framework on how to treat the motor disorders in children with CP. This graph is named "Gp(Graph) Treatment Modalities - Gross Motor Function" and is intended to facilitate communication between parents, therapists and medical doctors concerning (1) achievable motor function, (2) realistic goal-setting and (3) treatment perspectives for children with CP. The updated European consensus 2009 summarises the current understanding regarding an integrated, multidisciplinary treatment approach using Botulinum toxin for the treatment of children with CP. (C) 2009 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

引用

页码：45 / 66

页数：22

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