Physiological Plasticity of Neural-Crest-Derived Stem Cells in the Adult Mammalian Carotid Body

被引：47

作者：

Annese, Valentina ^{[1
]}

Navarro-Guerrero, Elena ^{[1
]}

Rodriguez-Prieto, Ismael ^{[1
]}

Pardal, Ricardo ^{[1
]}

机构：

[1] Univ Seville, Hosp Univ Virgen Rocio, CSIC, Dept Fisiol Med & Biofis,Inst Biomed Sevilla IBiS, Seville 41013, Spain

来源：

CELL REPORTS | 2017年 / 19卷 / 03期

关键词：

CHRONIC HYPOXIA; ENDOTHELIAL-CELLS; GENE-EXPRESSION; ERYTHROPOIETIN; PROGENITORS; DIFFERENTIATION; IDENTIFICATION; NEUROGENESIS; HYPERPLASIA; PATHWAY;

D O I：

10.1016/j.celrep.2017.03.065

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Adult stem cell plasticity, or the ability of somatic stem cells to cross boundaries and differentiate into unrelated cell types, has been a matter of debate in the last decade. Neural-crest-derived stem cells (NCSCs) display a remarkable plasticity during development. Whether adult populations of NCSCs retain this plasticity is largely unknown. Herein, we describe that neural-crest-derived adult carotid body stem cells (CBSCs) are able to undergo endothelial differentiation in addition to their reported role in neurogenesis, contributing to both neurogenic and angiogenic processes taking place in the organ during acclimatization to hypoxia. Moreover, CBSC conversion into vascular cell types is hypoxia inducible factor (HIF) dependent and sensitive to hypoxia-released vascular cytokines such as erythropoietin. Our data highlight a remarkable physiological plasticity in an adult population of tissue-specific stem cells and could have impact on the use of these cells for cell therapy.

引用

页码：471 / 478

页数：8

共 29 条

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