The function of E- and Id proteins in lymphocyte development

被引：162

作者：

Engel, I ^{[1
]}

Murre, C ^{[1
]}

机构：

[1] Univ Calif San Diego, Div Biol, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2001年 / 1卷 / 03期

关键词：

D O I：

10.1038/35105060

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Helix-loop-helix proteins are essential factors for lymphocyte development and function. In particular, E-proteins are crucial for commitment of lymphoid progenitors to the B- and T-cell lineages. E-proteins are negatively regulated by the Id class of helix-loop-helix proteins. The Id proteins function as dominant-negative inhibitors of E-proteins by inhibiting their ability to bind DNA. Here, we review the role of E-proteins and their Id protein antagonists in lymphocyte proliferation and developmental progression. In addition, we discuss how E-protein activity and Id gene expression are regulated by T-cell receptor (TCR) and pre-TCR-mediated signalling.

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页码：193 / 199

页数：7

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