Membrane topology of the metal-tetracycline/H+ antiporter TetA(K) from Staphylococcus aureus

被引：33

作者：

Ginn, SL ^{[1
]}

Brown, MH ^{[1
]}

Skurray, RA ^{[1
]}

机构：

[1] UNIV SYDNEY,SCH BIOL SCI A12,SYDNEY,NSW 2006,AUSTRALIA

来源：

JOURNAL OF BACTERIOLOGY | 1997年 / 179卷 / 11期

关键词：

D O I：

10.1128/jb.179.11.3786-3789.1997

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A series of fusions to the reporter proteins alkaline phosphatase and beta-galactosidase have been constructed in the predicted periplasmic and cytoplasmic loops of TetA(K), a protein responsible for efflux-mediated tetracycline resistance in Staphylococcus aureus. The results support a topological model of 14 transmembrane segments for TetA(K).

引用

页码：3786 / 3789

页数：4

共 27 条

[1]

ALLARD JD, 1992, J BIOL CHEM, V267, P17809

[2] ANALYSIS OF REGULATION OF ESCHERICHIA-COLI ALKALINE-PHOSPHATASE SYNTHESIS USING DELETIONS AND PHI-80 TRANSDUCING PHAGES [J].