Rescuing the function of mutant p53

被引：492

作者：

Bullock, AN

Fersht, A

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[2] Univ Cambridge, MRC, Ctr Prot Engn, Cambridge CB2 1EW, England

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期

关键词：

D O I：

10.1038/35094077

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

One protein - p53 - plays nemesis to most cancers by condemning damaged cells to death or quarantining them for repair. But the activity of p53 relies on its intact native conformation, which can be lost following mutation of a single nucleotide. With thousands of such mutations identified in patients, how can a future cancer drug buttress this fragile protein structure and restore the cell's natural defence?.

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页码：68 / 76

页数：9

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