Distinct striatal targets in treating obsessive-compulsive disorder and major depression Case report

被引：68

作者：

Aouizerate, Bruno ^{[1
,2
]}

Cuny, Emmanuel ^{[2
,3
]}

Bardinet, Eric ^{[5
]}

Yelnik, Jerome ^{[6
,7
]}

Martin-Guehl, Corinne ^{[1
]}

Rotge, Jean-Yves ^{[1
,2
]}

Rougier, Alain ^{[2
,3
]}

Bioulac, Bernard ^{[2
,4
]}

Tignol, Jean ^{[1
]}

Mallet, Luc ^{[8
,9
]}

Burbaud, Pierre ^{[2
,4
]}

Guehl, Dominique ^{[2
,4
]}

机构：

[1] Univ Bordeaux 2, Ctr Hosp Charles Perrens, Ctr Carreire, Psychiat Serv, Paris 13, France

[2] CNRS, Lab Mouvement Adaptat Cognit, Unite Mixte Rech 5227, Paris 13, France

[3] Hop Lariboisiere, Serv Neurochirurg, F-75010 Paris 13, France

[4] Univ Bordeaux 2, Ctr Hosp Univ Bordeaux, Serv Neurophysiol Clin, Paris 13, France

[5] Hop La Pitie Salpetriere, CNRS, Unite Propre Rech 640, Paris 13, France

[6] Hop La Pitie Salpetriere, Inst Natl Sante, Lab Neurol & Therapeut Expt, Paris 13, France

[7] Hop La Pitie Salpetriere, Rech Med Unite 679, Paris 13, France

[8] Inst Federatif Rech 70, Inst Natl Sante & Rech Med, Grp Avenir, Paris 13, France

[9] Hop La Pitie Salpetriere, Ctr Invest Clin, Paris 13, France

来源：

JOURNAL OF NEUROSURGERY | 2009年 / 111卷 / 04期

关键词：

obsessive-compulsive disorder; major depression; caudate nucleus; nucleus accumbens; deep brain stimulation; DEEP BRAIN-STIMULATION; NUCLEUS; EMOTION; OCD;

D O I：

10.3171/2009.2.JNS0881

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The ventral striatum, including the head of the caudate nucleus and the nucleus accumbens, is a putative target for deep brain stimulation (DBS) in the treatment of obsessive-compulsive disorder (OCD) and major depression (MD). However, the respective roles of these structures in the pathophysiology of OCD and MD remain to be clarified. To address this issue, DBS of the ventral striatum was tested in 2 patients with severely distressing and intractable forms of OCD and MD. Comparisons of clinical outcomes and anatomical data on electrode positioning showed that caudate nucleus stimulation preferentially alleviated OCD manifestations, whereas nucleus accumbens stimulation improved depressive symptoms. These findings suggest that the caudate nucleus and nucleus accumbens participate differently in the pathogenesis of both of these psychiatric conditions. (DOI: 10.3171/2009.2.JNS0881)

引用

页码：775 / 779

页数：5

共 27 条

[1] Deep brain stimulation for refractory obsessive-compulsive disorder [J].

Abelson, JL ;

Curtis, GC ;

Sagher, O ;

Albucher, RC ;

Harrigan, M ;

Taylor, SF ;

Martis, B ;

Giordani, B .

BIOLOGICAL PSYCHIATRY, 2005, 57 (05) :510-516

[2] Deep brain stimulation for OCD and major depression [J].

Aouizerate, B ;

Martin-Guehl, C ;

Cuny, E ;

Guehl, D ;

Amieva, H ;

Benazzouz, A ;

Fabrigoule, C ;

Bioulac, B ;

Tignol, J ;

Burbaud, P .

AMERICAN JOURNAL OF PSYCHIATRY, 2005, 162 (11) :2192-2192

[3] Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression - Case report [J].

Aouizerate, B ;

Cuny, E ;

Martin-Guehl, C ;

Guehl, D ;

Amieva, H ;

Benazzouz, A ;

Fabrigoule, C ;

Allard, M ;

Rougier, A ;

Bioulac, B ;

Tignol, J ;

Burbaud, P .

JOURNAL OF NEUROSURGERY, 2004, 101 (04) :682-686

[4] Pathophysiology of obsessive-compulsive disorder - A necessary link between phenomenology, neuropsychology, imagery and physiology [J].

Aouizerate, B ;

Guehl, D ;

Cuny, E ;

Rougier, A ;

Bioulac, B ;

Tignol, J ;

Burbaud, P .

PROGRESS IN NEUROBIOLOGY, 2004, 72 (03) :195-221

[5]

BALL A, 1999, NZ J ENV HLTH, V22, P29

[6]

Baxter L R., 1999, Neurobiology of Mental Illness, P534

[7] Patient-speciftic analysis of the volume of tissue activated during deep brain stimulation [J].

Butson, Christopher R. ;

Cooper, Scott E. ;

Henderson, Jaimie M. ;

McIntyre, Cameron C. .

NEUROIMAGE, 2007, 34 (02) :661-670

[8] FRONTAL-SUBCORTICAL CIRCUITS AND HUMAN-BEHAVIOR [J].

CUMMINGS, JL .

ARCHIVES OF NEUROLOGY, 1993, 50 (08) :873-880

[9] The functional neuroanatomy of emotion and affective style [J].

Davidson, RJ ;

Irwin, W .

TRENDS IN COGNITIVE SCIENCES, 1999, 3 (01) :11-21

[10] Neuroimaging studies of mood disorders [J].

Drevets, WC .

BIOLOGICAL PSYCHIATRY, 2000, 48 (08) :813-829

← 1 2 3 →