Maternal birthweight and diet in pregnancy in relation to the infant's thinness at birth

被引:111
作者
Godfrey, KM
Barker, DJP
Robinson, S
Osmond, C
机构
[1] Medical Research Council Environmental Epidemiology Unit (University of Southampton), Southampton General Hospital
来源
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 1997年 / 104卷 / 06期
关键词
D O I
10.1111/j.1471-0528.1997.tb11975.x
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective To examine how maternal diet in pregnancy and parental body size and birthweight influence an infant's thinness at birth measured by a low ponderal index. Design An observational study of newborn infants and their parents. Setting Southampton, England. Population Five hundred and thirty-eight infants born at term. Main outcome measure Ponderal index at birth. Results Women who had a high intake of carbohydrate in early pregnancy and a low intake of dairy protein in late pregnancy tended to have infants that were thin at birth (P = 0.01 and P = 0.03, respectively, in a simultaneous analysis). Women who themselves had a low birthweight also tended to have thin infants, ponderal index falling from 28.3 kg/m(3) to 26.2 kg/m(3) as the women's birthweights decreased from more than 4.0 kg to 2.5 kg or less (P < 0.0001). Tall fathers had thin infants, but ponderal index was not related to the women's heights or the fathers' birthweights. Conclusion These associations may reflect constraints on placental development imposed by a woman's nutrition in pregnancy and during her own intrauterine life. Effects of the father's height may be mediated through genetic influences on skeletal growth.
引用
收藏
页码:663 / 667
页数:5
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共 29 条
  • [1] [Anonymous], 2010, PORT CLASS OCC
  • [2] Barker D J, 1992, Paediatr Perinat Epidemiol, V6, P35, DOI 10.1111/j.1365-3016.1992.tb00741.x
  • [3] TYPE 2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS, HYPERTENSION AND HYPERLIPEMIA (SYNDROME-X) - RELATION TO REDUCED FETAL GROWTH
    BARKER, DJP
    HALES, CN
    FALL, CHD
    OSMOND, C
    PHIPPS, K
    CLARK, PMS
    [J]. DIABETOLOGIA, 1993, 36 (01) : 62 - 67
  • [4] FETAL ORIGINS OF CORONARY HEART-DISEASE
    BARKER, DJP
    [J]. BRITISH MEDICAL JOURNAL, 1995, 311 (6998) : 171 - 174
  • [5] THE RELATION OF SMALL HEAD CIRCUMFERENCE AND THINNESS AT BIRTH TO DEATH FROM CARDIOVASCULAR-DISEASE IN ADULT LIFE
    BARKER, DJP
    OSMOND, C
    SIMMONDS, SJ
    WIELD, GA
    [J]. BRITISH MEDICAL JOURNAL, 1993, 306 (6875) : 422 - 426
  • [6] BOTTING B, 1993, POPULATION TRENDS, V74, P27
  • [7] BIRTH-WEIGHT - NATURE OR NURTURE
    BROOKS, AA
    JOHNSON, MR
    STEER, PJ
    PAWSON, ME
    ABDALLA, HI
    [J]. EARLY HUMAN DEVELOPMENT, 1995, 42 (01) : 29 - 35
  • [8] IDENTIFICATION OF THE SMALL-FOR-GESTATIONAL-AGE FETUS WITH THE USE OF GESTATIONAL-AGE INDEPENDENT INDEXES OF FETAL GROWTH
    DIVON, MY
    CHAMBERLAIN, PF
    SIPOS, L
    MANNING, FA
    PLATT, LD
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 155 (06) : 1197 - 1201
  • [9] INTERGENERATIONAL STUDIES OF HUMAN BIRTH-WEIGHT FROM THE 1958 BIRTH COHORT .1. EVIDENCE FOR A MULTIGENERATIONAL EFFECT
    EMANUEL, I
    FILAKTI, H
    ALBERMAN, E
    EVANS, SJW
    [J]. BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1992, 99 (01): : 67 - 74
  • [10] GLUCKMAN PD, 1990, ACTA PAEDIATR SCAND, P105