Stereocontrolled Synthesis of C1-C17 Fragment of Narasin via a Free Radical-Based Approach

被引：17

作者：

Brazeau, Jean-Francois

Guilbault, Audrey-Anne

Kochuparampil, Jummey

Mochirian, Philippe

Guindon, Yvan ^{[1
]}

机构：

[1] Inst Rech Clin Montreal, Montreal, PQ H2W 1R7, Canada

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ALDOL REACTIONS; ALDEHYDES; STRATEGY; ASSEMBLAGE; MUKAIYAMA; ALCOHOLS; MOTIFS;

D O I：

10.1021/ol902414u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the C1-C17 western unit of narasin was achieved from (S)-Roche ester. Highlights in our synthesis include the successful exploitation of three stereoselective sequences of Lewis acid mediated reaction followed by free-radical-based hydrogen transfer.

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收藏

页码：36 / 39

页数：4

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