Enantiopure β-hydroxy morpholine amides from terminal epoxides by carbonylation at 1 atm

被引：46

作者：

Goodman, SN ^{[1
]}

Jacobsen, EN ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2002年 / 41卷 / 24期

关键词：

amides; carbonylation; cobalt; epoxides; homogeneous catalysis;

D O I：

10.1002/anie.200290022

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Keeping the CO pressure down is a crucial, practical feature of the new methodology for the carbonylation of terminal epoxides. β-Hydroxy morpholinyl amides are generated directly in optically pure form [Eq. (1)], and these building blocks can be applied in a variety of acyl transfer reactions. A useful illustration is provided in the concise synthesis of δ-hydroxy-β-ketoesters, key intermediates for the preparation of the statin class of HMG-CoA reductase inhibitors.

引用

页码：4703 / 4705

页数：3

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