The interactions of trialkyltin compounds with lysosomes from rat liver

被引：10

作者：

Bragadin, M

Marton, D

Scutari, G

Dell'Antone, P

机构：

[1] Univ Venice, Dipartimento Sci Ambientali, I-30123 Venice, Italy

[2] Univ Padua, Dipartimento Chim Inorgan Metallorgan & Anali, I-35131 Padua, Italy

[3] Univ Padua, Dipartimento Chim Biol, I-35121 Padua, Italy

[4] Univ Padua, Dipartimento Sci Biomed Sperimentali, I-35121 Padua, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2000年 / 78卷 / 03期

关键词：

lysosomes; trialkyltin; uncoupling;

D O I：

10.1016/S0162-0134(00)00004-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interactions of two trialkyltin compounds with the lysosomes from a rat liver have been studied. It is shown that these compounds induce a fast alkalinisation in the matrix of energised lysosomes. The fast alkalinisation rate is similar to the one obtained with uncouplers of the oxidative phosphorylation. An identical effect has been obtained with lysosomes energised in a chloride Free medium. This supports the hypothesis that trialkyltin compounds behave not only as Cl- /OH- exchangers, but also as proton carriers in biological membranes. This result could explain the toxicity and in particular the neurotoxicity of trialkyltin compounds. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：205 / 207

页数：3

共 17 条

[1] OXIDATIVE-PHOSPHORYLATION - HALIDE-DEPENDENT AND HALIDE-INDEPENDENT EFFECTS OF TRIORGANOTIN AND TRIORGANO-LEAD COMPOUNDS ON MITOCHONDRIAL FUNCTIONS [J].