A complex oscillating network of signaling genes underlies the mouse segmentation clock

被引：339

作者：

Dequeant, Mary-Lee

Glynn, Earl

Gaudenz, Karin

Wahl, Matthias

Chen, Jie

Mushegian, Arcady

Pourquie, Olivier ^{[1
]}

机构：

[1] Howard Hughes Med Inst, Kansas City, MO 64110 USA

[2] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA

[3] Stowers Inst Med Res, Kansas City, MO 64110 USA

[4] Univ Missouri, Dept Math & Stat, Kansas City, MO 64110 USA

来源：

SCIENCE | 2006年 / 314卷 / 5805期

关键词：

D O I：

10.1126/science.1133141

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The segmental pattern of the spine is established early in development, when the vertebral precursors, the somites, are rhythmically produced from the presomitic mesoderm. Microarray studies of the mouse presomitic mesoderm transcriptome reveal that the oscillator associated with this process, the segmentation clock, drives the periodic expression of a large network of cyclic genes involved in cell signaling. Mutually exclusive activation of the notch-fibroblast growth factor and Wnt pathways during each cycle suggests that coordinated regulation of these three pathways underlies the clock oscillator.

引用

收藏

页码：1595 / 1598

页数：4

相关论文

共 21 条

[1] Wnt3A plays a major role in the segmentation clock controlling somitogenesis [J].

Aulehla, A ;

Wehrle, C ;

Brand-Saberi, B ;

Kemler, R ;

Gossler, A ;

Kanzler, B ;

Herrmann, BG .

DEVELOPMENTAL CELL, 2003, 4 (03) :395-406

[2] Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm [J].

Buttitta, L ;

Tanaka, TS ;

Chen, AE ;

Ko, MSH ;

Fan, CM .

DEVELOPMENTAL BIOLOGY, 2003, 258 (01) :91-104

[3] Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme [J].

Camenisch, TD ;

Spicer, AP ;

Brehm-Gibson, T ;

Biesterfeldt, J ;

Augustine, ML ;

Calabro, A ;

Kubalak, S ;

Klewer, SE ;

McDonald, JA .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (03) :349-360

[4] FGF-20 and DKK1 are transcriptional targets of β-catenin and FGF-20 is implicated in cancer and development [J].

Chamorro, MN ;

Schwartz, DR ;

Vonica, A ;

Brivanlou, AH ;

Cho, KR ;

Varmus, HE .

EMBO JOURNAL, 2005, 24 (01) :73-84

[5] Dynamic complex formation during the yeast cell cycle [J].

de Lichtenberg, U ;

Jensen, LJ ;

Brunak, S ;

Bork, P .

SCIENCE, 2005, 307 (5710) :724-727

[6] Control of the segmentation process by graded MAPK/ERK activation in the chick embryo [J].

Delfini, MC ;

Dubrulle, J ;

Malapert, P ;

Chal, J ;

Pourquié, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (32) :11343-11348

[7] FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation [J].

Dubrulle, J ;

McGrew, MJ ;

Pourquié, O .

CELL, 2001, 106 (02) :219-232

[8]

EBIAGHIE MC, 2003, CURR BIOL, V13, P1009

[9] Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury [J].

Harrison, SM ;

Houzelstein, D ;

Dunwoodie, SL ;

Beddington, RSP .

DEVELOPMENTAL BIOLOGY, 2000, 227 (02) :358-372

[10] Identification of c-MYC as a target of the APC pathway [J].

He, TC ;

Sparks, AB ;

Rago, C ;

Hermeking, H ;

Zawel, L ;

da Costa, LT ;

Morin, PJ ;

Vogelstein, B ;

Kinzler, KW .

SCIENCE, 1998, 281 (5382) :1509-1512