学术探索
学术期刊
新闻热点
数据分析
智能评审

Reduction of benzodiazepine receptor binding is related to the seizure onset zone in extratemporal focal cortical dysplasia

被引：36
作者：
Arnold, S
Berthele, A
Drzezga, A
Tölle, TR
Weis, S
Werhahn, KJ
Henkel, A
Yousry, TA
Winkler, PA
Bartenstein, P
Noachtar, S
机构：
[1] Univ Munich, Dept Neurol, D-81377 Munich, Germany
[2] Univ Munich, Dept Neuropathol, D-81377 Munich, Germany
[3] Univ Munich, Dept Neuroradiol, D-81377 Munich, Germany
[4] Univ Munich, Dept Neurosurg, D-81377 Munich, Germany
[5] Tech Univ Munich, Dept Neurol, D-8000 Munich, Germany
[6] Tech Univ Munich, Dept Nucl Med, D-8000 Munich, Germany
来源：
EPILEPSIA | 2000年 / 41卷 / 07期
关键词：
frontal lobe epilepsy; focal cortical dysplasia; positron emission tomography; benzodiazepine receptor;
D O I：
10.1111/j.1528-1157.2000.tb00248.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Purpose: Comparison of regional reduction of GABA receptor binding and seizure onset zone in patients with extratemporal epilepsy due to focal cortical dysplasia. Methods: Two patients with frontal lobe epilepsy who remained seizure free after partial frontal lobe resection were investigated with magnetic resonance imaging, positron emission tomography (PET) with F-18-fluoro-deoxy-glucose (FDG) and C-11-flumazenil, subdural EEG-video recordings, and postoperative benzodiazepine (BDZ)-receptor autoradiography. Results: The area of reduced BDZ-receptor binding as documented by preoperative flumazenil-PET and postoperative BDZ-receptor autoradiography corresponded to the seizure on-set zone and was smaller than the interictal hypometabolism documented by FDG-PET. Conclusion: Flumazenil-PET is a useful tool for localization of the epileptogenic zone in patients with extratemporal epilepsy caused by focal cortical dysplasia. Neuronal distribution of BDZ-receptor density confirms in vivo flumazenil-PET findings. The regional reduction of BDZ-receptor binding in focal cortical dysplasia seems to be confined to the seizure onset zone and not to the extent of dysplastic cortex.
引用
收藏
页码：818 / 824
页数：7
相关论文
共 18 条
[1]   Topography of interictal glucose hypometabolism in unilateral mesiotemporal epilepsy [J].
Arnold, S ;
Schlaug, G ;
Niemann, H ;
Ebner, A ;
Luders, H ;
Witte, OW ;
Seitz, RJ .
NEUROLOGY, 1996, 46 (05) :1422-1430
[2]   Neuronal migration disorders and epilepsy: A morphological analysis of three surgically treated patients [J].
Battaglia, G ;
Arcelli, P ;
Granata, T ;
Selvaggio, M ;
Andermann, F ;
Dubeau, F ;
Olivier, A ;
Tampieri, D ;
Villemure, JG ;
Avoli, M ;
Avanzini, G ;
Spreafico, R .
EPILEPSY RESEARCH, 1996, 26 (01) :49-58
[3]   TEMPORAL-LOBE CENTRAL BENZODIAZEPINE BINDING IN UNILATERAL MESIAL TEMPORAL-LOBE EPILEPSY [J].
BURDETTE, DE ;
SAKURAI, SY ;
HENRY, TR ;
ROSS, DA ;
PENNELL, PB ;
FREY, KA ;
SACKELLARES, JC ;
ALBIN, RL .
NEUROLOGY, 1995, 45 (05) :934-941
[4]   Is C-11-flumazenil PET superior to (18)FDG PET and I-123-iomazenil SPECT in presurgical evaluation of temporal lobe epilepsy? [J].
Debets, RMC ;
Sadzot, B ;
vanIsselt, JW ;
Brekelmans, GJF ;
Meiners, LC ;
vanHuffelen, AC ;
Franck, G ;
vanVeelen, CWM .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1997, 62 (02) :141-150
[5]   QUANTIFYING INTERICTAL METABOLIC-ACTIVITY IN HUMAN TEMPORAL-LOBE EPILEPSY [J].
HENRY, TR ;
MAZZIOTTA, JC ;
ENGEL, J ;
CHRISTENSON, PD ;
ZHANG, JX ;
PHELPS, ME ;
KUHL, DE .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1990, 10 (05) :748-757
[6]   IN-VIVO CEREBRAL METABOLISM AND CENTRAL BENZODIAZEPINE-RECEPTOR BINDING IN TEMPORAL-LOBE EPILEPSY [J].
HENRY, TR ;
FREY, KA ;
SACKELLARES, JC ;
GILMAN, S ;
KOEPPE, RA ;
BRUNBERG, JA ;
ROSS, DA ;
BERENT, S ;
YOUNG, AB ;
KUHL, DE .
NEUROLOGY, 1993, 43 (10) :1998-2006
[7]   Cerebral benzodiazepine receptors in hippocampal sclerosis - An objective in vivo analysis [J].
Koepp, MJ ;
Richardson, MP ;
Brooks, DJ ;
Poline, JB ;
VanPaesschen, W ;
Friston, KJ ;
Duncan, JS .
BRAIN, 1996, 119 :1677-1687
[8]   COMPARTMENTAL ANALYSIS OF [C-11] FLUMAZENIL KINETICS FOR THE ESTIMATION OF LIGAND TRANSPORT RATE AND RECEPTOR DISTRIBUTION USING POSITRON EMISSION TOMOGRAPHY [J].
KOEPPE, RA ;
HOLTHOFF, VA ;
FREY, KA ;
KILBOURN, MR ;
KUHL, DE .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1991, 11 (05) :735-744
[9]   BENZODIAZEPINE RECEPTOR QUANTIFICATION IN-VIVO IN HUMANS USING [C-11] FLUMAZENIL AND PET - APPLICATION OF THE STEADY-STATE PRINCIPLE [J].
LASSEN, NA ;
BARTENSTEIN, PA ;
LAMMERTSMA, AA ;
PREVETT, MC ;
TURTON, DR ;
LUTHRA, SK ;
OSMAN, S ;
BLOOMFIELD, PM ;
JONES, T ;
PATSALOS, PN ;
OCONNELL, MT ;
DUNCAN, JS ;
ANDERSEN, JV .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (01) :152-165
[10]  
MINOSHIMA S, 1994, J NUCL MED, V35, P949
12