A Cell Culture (Vero)-Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses

被引：44

作者：

Ehrlich, Hartmut J.

Mueller, Markus ^{[1
]}

Fritsch, Sandor

Zeitlinger, Markus ^{[1
]}

Berezuk, Greg

Loew-Baselli, Alexandra

van der Velden, Maikel V. W.

Poellabauer, Eva Maria

Maritsch, Friedrich

Pavlova, Borislava G.

Tambyah, Paul A. ^{[2
]}

Oh, Helen M. L. ^{[3
]}

Montomoli, Emanuele ^{[4
]}

Kistner, Otfried

Barrett, P. Noel

机构：

[1] Med Univ Vienna, Dept Clin Pharmacol, Vienna Gen Hosp, A-1090 Vienna, Austria

[2] Natl Univ Singapore, Singapore 117548, Singapore

[3] Changi Gen Hosp, Singapore, Singapore

[4] Univ Siena, I-53100 Siena, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 07期

关键词：

PANDEMIC INFLUENZA VACCINE; MF59-ADJUVANTED INFLUENZA; IMMUNITY; TRIAL; SAFETY;

D O I：

10.1086/605608

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-mu g dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic.

引用

页码：1113 / 1118

页数：6

共 15 条

[1]

[Anonymous], CUM NUMB CONF HUM CA

[2] A clinical trial of a whole-virus H5N1 vaccine derived from cell culture [J].

Ehrlich, Hartmut J. ;

Mueller, Markus ;

Oh, Helen M. L. ;

Tambyah, Paul A. ;

Joukhadar, Christian ;

Montomoli, Emanuele ;

Fisher, Dale ;

Berezuk, Greg ;

Fritsch, Sandor ;

Loew-Baselli, Alexandra ;

Vartian, Nina ;

Bobrovsky, Roman ;

Pavlova, Borislava G. ;

Poellabauer, Eva Maria ;

Kistner, Otfried ;

Barrett, P. Noel .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (24) :2573-2584

[3] Strategies for mitigating an influenza pandemic [J].

Ferguson, Neil M. ;

Cummings, Derek A. T. ;

Fraser, Christophe ;

Cajka, James C. ;

Cooley, Philip C. ;

Burke, Donald S. .

NATURE, 2006, 442 (7101) :448-452

[4] Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variant [J].

Goji, Nega Ali ;

Nolan, Carrie ;

Hill, Heather ;

Wolff, Mark ;

Noah, Diana L. ;

Williams, Tracy B. ;

Rowe, Thomas ;

Treanor, John J. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (05) :635-641

[5] Broad Clade 2 Cross-Reactive Immunity Induced by an Adjuvanted Clade 1 rH5N1 Pandemic Influenza Vaccine [J].

Leroux-Roels, Isabel ;

Bernhard, Roger ;

Gerard, Pascal ;

Drame, Mamadou ;

Hanon, Emmanuel ;

Leroux-Roels, Geert .

PLOS ONE, 2008, 3 (02)

[6] Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine:: a randomised controlled trial [J].

Leroux-Roels, Isabel ;

Borkowski, Astrid ;

Vanwolleghem, Thomas ;

Drame, Mamadou ;

Clement, Frederic ;

Hons, Eliane ;

Devaster, Jeanne-Marie ;

Leroux-Roels, Geert .

LANCET, 2007, 370 (9587) :580-589

[7] Multiple sublineages of influenza a virus (H5N1), Vietnam, 2005-2007 [J].

Nguyen, Tien Dung ;

Nguyen, Vinh ;

Vijaykrishna, Dhanasekaran ;

Webster, Robert G. ;

Guan, Yi ;

Peiris, J. S. Malik ;

Smith, Gavin J. D. .

EMERGING INFECTIOUS DISEASES, 2008, 14 (04) :632-636

[8] Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza [J].

Nicholson, KG ;

Colegate, AE ;

Podda, A ;

Stephenson, I ;

Wood, J ;

Ypma, E ;

Zambon, MC .

LANCET, 2001, 357 (9272) :1937-1943

[9] CLINICAL STUDIES OF MONO-VALENT INACTIVATED WHOLE VIRUS AND SUBUNIT A-USSR-77 (H1N1) VACCINE - SEROLOGICAL RESPONSES AND CLINICAL REACTIONS [J].

NICHOLSON, KG ;

TYRRELL, DAJ ;

HARRISON, P ;

POTTER, CW ;

JENNINGS, R ;

CLARK, A ;

SCHILD, GC ;

WOOD, JM ;

YETTS, R ;

SEAGROATT, V ;

HUGGINS, A ;

ANDERSON, SG .

JOURNAL OF BIOLOGICAL STANDARDIZATION, 1979, 7 (02) :123-136

[10]

SCHILD GC, 1975, B WORLD HEALTH ORGAN, V52, P43

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