Monoamine oxidase and cigarette smoking

被引:163
作者
Fowler, JS [1 ]
Logan, J [1 ]
Wang, GJ [1 ]
Volkow, ND [1 ]
机构
[1] Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA
基金
美国国家卫生研究院;
关键词
monoamine oxidase; tobacco; cigarette smoking; positron emission tomography; smoking epidemiology; smoking cessation;
D O I
10.1016/S0161-813X(02)00109-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Current cigarette smokers have reduced monoamine oxidase (MAO) and there is evidence that this is a pharmacological effect of tobacco smoke exposure rather than a biological characteristic of smokers. This article summarizes human and animal studies documenting the inhibitory effects of tobacco smoke on MAO and discusses MAO inhibition in the context of smoking epidemiology, MAO inhibitor compounds in tobacco, reinvestigations of low platelet MAO in psychiatric disorders and smoking cessation. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:75 / 82
页数:8
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