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Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa

被引：100
作者：
Haas, WH
Schilke, K
Brand, J
Amthor, B
Weyer, K
Fourie, PB
Bretzel, G
StichtGroh, V
Bremer, HJ
机构：
[1] GERMAN LEPROSY RELIEF ASSOC,ARMAUER HANSEN RES INST,MYCOBACTERIOL LAB,WURZBURG,GERMANY
[2] S AFRICAN MRC,TB RES INST,PRETORIA,SOUTH AFRICA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 07期
关键词：
D O I：
10.1128/AAC.41.7.1601
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.
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页码：1601 / 1603
页数：3
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