Telomerase unplugged

被引：14

作者：

Cristofari, Gael

Sikora, Katarzyna

Lingner, Joachim ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

[2] NCCR, Program Frontiers Genet, CH-1066 Epalinges, Switzerland

来源：

ACS CHEMICAL BIOLOGY | 2007年 / 2卷 / 03期

关键词：

D O I：

10.1021/cb700037c

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

引用

收藏

页码：155 / 158

页数：4

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