Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE

被引：133

作者：

Masliah, E ^{[1
]}

Samuel, W ^{[1
]}

Veinbergs, I ^{[1
]}

Mallory, M ^{[1
]}

Mante, M ^{[1
]}

Saitoh, T ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,SCH MED,DEPT PATHOL,LA JOLLA,CA 92093

来源：

BRAIN RESEARCH | 1997年 / 751卷 / 02期

关键词：

apoE-deficient mouse; neurotrophic; neurodegeneration; synapse; Alzheimer's disease;

D O I：

10.1016/S0006-8993(96)01420-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies suggest that apolipoprotein E (apoE) might play a neurotrophic function in the central nervous system and that altered functioning of this molecule could result in neurodegeneration. The main objective of this study was to determine if neurodegenerative and cognitive alterations in apoE-deficient mice are reversible by infusion of recombinant apoE into the lateral ventricles. ApoE-deficient mice treated with either apoES or apoE4 showed a significant improvement in their learning capacity in the Morris water maze compared to saline-infused apoE-deficient mice. While this improved performance was associated with restoration of neuronal structure, the poor learning ability of apoE-deficient mice treated with saline correlated with the disrupted synapto-dendritic structure. This study supports the contention that apoE might play a neurotrophic effect in vivo and suggests that apoE might have a potential therapeutic role. (C) 1997 Elsevier Science B.V.

引用

页码：307 / 314

页数：8

共 29 条

[1]

ALLAIN CC, 1974, CLIN CHEM, V20, P470

[2] APOLIPOPROTEIN-E ASSOCIATED WITH ASTROCYTIC GLIA OF THE CENTRAL NERVOUS-SYSTEM AND WITH NONMYELINATING GLIA OF THE PERIPHERAL NERVOUS-SYSTEM [J].

BOYLES, JK ;

PITAS, RE ;

WILSON, E ;

MAHLEY, RW ;

TAYLOR, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (04) :1501-1513

[3] SYNAPTIC LOSS IN COGNITIVELY IMPAIRED AGED RATS IS AMELIORATED BY CHRONIC HUMAN NERVE GROWTH-FACTOR INFUSION [J].

CHEN, KS ;

MASLIAH, E ;

MALLORY, M ;

GAGE, FH .

NEUROSCIENCE, 1995, 68 (01) :19-27

[4] APOLIPOPROTEIN-E MESSENGER-RNA IS ABUNDANT IN THE BRAIN AND ADRENALS, AS WELL AS IN THE LIVER, AND IS PRESENT IN OTHER PERIPHERAL-TISSUES OF RATS AND MARMOSETS [J].

ELSHOURBAGY, NA ;

LIAO, WS ;

MAHLEY, RW ;

TAYLOR, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (01) :203-207

[5]

Gandy S., 1995, Society for Neuroscience Abstracts, V21, P5

[6] MEMORY DEFICITS AND CHOLINERGIC IMPAIRMENTS IN APOLIPOPROTEIN E-DEFICIENT MICE [J].

GORDON, I ;

GRAUER, E ;

GENIS, I ;

SEHAYEK, E ;

MICHAELSON, DM .

NEUROSCIENCE LETTERS, 1995, 199 (01) :1-4

[7] APOLIPOPROTEIN-E IS LOCALIZED TO THE CYTOPLASM OF HUMAN CORTICAL-NEURONS - A LIGHT AND ELECTRON-MICROSCOPIC STUDY [J].

HAN, SH ;

EINSTEIN, G ;

WEISGRABER, KH ;

STRITTMATTER, WJ ;

SAUNDERS, AM ;

PERICAKVANCE, M ;

ROSES, AD ;

SCHMECHEL, DE .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1994, 53 (05) :535-544

[8] APOLIPOPROTEIN-E IS PRESENT IN HIPPOCAMPAL-NEURONS WITHOUT NEUROFIBRILLARY TANGLES IN ALZHEIMERS-DISEASE AND IN AGE-MATCHED CONTROLS [J].

HAN, SH ;

HULETTE, C ;

SAUNDERS, AM ;

EINSTEIN, G ;

PERICAKVANCE, M ;

STRITTMATTER, WJ ;

ROSES, AD ;

SCHMECHEL, DE .

EXPERIMENTAL NEUROLOGY, 1994, 128 (01) :13-26

[9] LOW-DENSITY-LIPOPROTEIN RECEPTOR-RELATED PROTEIN MEDIATES APOLIPOPROTEIN E-DEPENDENT NEURITE OUTGROWTH IN A CENTRAL NERVOUS SYSTEM-DERIVED NEURONAL CELL-LINE [J].

HOLTZMAN, DM ;

PITAS, RE ;

KILBRIDGE, J ;

NATHAN, B ;

MAHLEY, RW ;

BU, GJ ;

SCHWARTZ, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (21) :9480-9484

[10] ISOFORM-SPECIFIC INTERACTIONS OF APOLIPOPROTEIN-E WITH THE MICROTUBULE-ASSOCIATED PROTEIN MAP2C - IMPLICATIONS FOR ALZHEIMERS-DISEASE [J].

HUANG, DY ;

GOEDERT, M ;

JAKES, R ;

WEISGRABER, KH ;

GARNER, CC ;

SAUNDERS, AM ;

PERICAKVANCE, MA ;

SCHMECHEL, DE ;

ROSES, AD ;

STRITTMATTER, WJ .

NEUROSCIENCE LETTERS, 1994, 182 (01) :55-58

← 1 2 3 →