Purinergic mechanosensory transduction and visceral pain

被引：91

作者：

Burnstock, Geoffrey ^{[1
]}

机构：

[1] Royal Free & Univ Coll Med Sch, Auton Neurosci Ctr, London NW3 2PF, England

来源：

MOLECULAR PAIN | 2009年 / 5卷

关键词：

URINARY-BLADDER; SENSORY NEURONS; P2X RECEPTORS; ATP RELEASE; ADENOSINE-TRIPHOSPHATE; DORSAL-ROOT; ANTISENSE OLIGONUCLEOTIDES; SUBEPITHELIAL FIBROBLASTS; VAGAL MECHANORECEPTORS; DETRUSOR OVERACTIVITY;

D O I：

10.1186/1744-8069-5-69

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain. Experimental evidence for this mechanism in urinary bladder, ureter, gut, lung, uterus, tooth-pulp and tongue is reviewed. Potential therapeutic strategies are considered for the treatment of visceral pain in such conditions as renal colic, interstitial cystitis and inflammatory bowel disease by agents that interfere with mechanosensory transduction in the organs considered, including P2X(3) and P2X(2/3) receptor antagonists that are orally bioavailable and stable in vivo and agents that inhibit or enhance ATP release and breakdown.

引用

页数：12

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