Apparent Transverse Relaxation Rates in Systems with Scalar-Coupled Protons

被引：22

作者：

Baishya, Bikash ^{[1
]}

Segawa, Takuya F. ^{[1
]}

Bodenhausen, Geoffrey ^{[1
,2
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, BCH, CH-1015 Lausanne, Switzerland

[2] Ecole Normale Super, Dept Chim, Associe CNRS, F-75231 Paris 05, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 48期

基金：

瑞士国家科学基金会;

关键词：

QUENCHING ECHO MODULATIONS; PEPTIDE CONFORMATIONS; NMR-SPECTROSCOPY; CYCLOSPORIN-A; HOMONUCLEAR; DEPENDENCE; DYNAMICS;

D O I：

10.1021/ja907391z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) The modulation of spin echoes by homonuclear scalar couplings render the determination of transverse relaxation rates of individual spins difficult, in particular for molecules that are isotopically enriched in 13C or 15N, and for all molecules with scalar-coupled protons. To avoid echo modulations, most studies using refocusing pulses have so far been restricted to isolated 1H, 13C, or 15N spins. We report measurements of apparent 1H transverse relaxation rates of backbone and side-chain protons in Cyclosporin A (CsA) determined by quenching the echo modulations that arise from homonuclear scalar couplings between protons. © 2009 American Chemical Society.

引用

页码：17538 / 17539

页数：2

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