Genetic basis of tolerance to O-2 deprivation in Drosophila melanogaster

被引:70
作者
Haddad, GG
Sun, YA
Wyman, RJ
Xu, T
机构
[1] YALE UNIV,SCH MED,DEPT BIOL,NEW HAVEN,CT 06520
[2] YALE UNIV,SCH MED,DEPT GENET,NEW HAVEN,CT 06520
[3] YALE UNIV,SCH MED,BOYER CTR MOL MED,NEW HAVEN,CT 06520
关键词
D O I
10.1073/pnas.94.20.10809
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The ability to tolerate a low-O-2 environment varies widely among species in the animal kingdom. Some animals, such as Drosophila melanogaster, can tolerate anoxia for prolonged periods without apparent tissue injury, To determine the genetic basis of the cellular responses to low O-2, we performed a genetic screen in Drosophila to identify loci that are responsible for anoxia resistance. Four X-linked, anoxia-sensitive mutants belonging to three complementation groups were isolated after screening more than 10,000 mutagenized flies. The identified recessive and dominant mutations showed marked delay in recovery from O-2 deprivation. In addition, electrophysiologic studies demonstrated that polysynaptic transmission in the central nervous system of the mutant flies was abnormally long during recovery from anoxia. These studies show that anoxic tolerance can be genetically dissected.
引用
收藏
页码:10809 / 10812
页数:4
相关论文
共 24 条
[1]   NOTCH SIGNALING [J].
ARTAVANISTSAKONAS, S ;
MATSUNO, K ;
FORTINI, ME .
SCIENCE, 1995, 268 (5208) :225-232
[2]  
BAIRD DH, 1990, GENETICS, V126, P1045
[3]   ELUCIDATION OF BIOPHYSICAL AND BIOLOGICAL PROPERTIES OF VOLTAGE-GATED POTASSIUM CHANNELS [J].
BALDWIN, TJ ;
ISACOFF, E ;
LI, M ;
LOPEZ, GA ;
SHENG, M ;
TSAUR, ML ;
JAN, YN ;
JAN, LY .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1992, 57 :491-499
[4]   RAS SIGNAL-TRANSDUCTION PATHWAY IN DROSOPHILA EYE DEVELOPMENT [J].
CHANG, HC ;
KARIM, FD ;
ONEILL, EM ;
REBAY, I ;
SOLOMON, NM ;
THERRIEN, M ;
WASSARMAN, DA ;
WOLFF, T ;
RUBIN, GM .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1994, 59 :147-153
[5]  
CHOI DW, 1990, ANNU REV NEUROSCI, V13, P171, DOI 10.1146/annurev.neuro.13.1.171
[6]   EXTENSIVE INTRACELLULAR TRANSLOCATIONS OF A MAJOR PROTEIN ACCOMPANY ANOXIA IN EMBRYOS OF ARTEMIA-FRANCISCANA [J].
CLEGG, JS ;
JACKSON, SA ;
WARNER, AH .
EXPERIMENTAL CELL RESEARCH, 1994, 212 (01) :77-83
[7]   EFFECT OF METABOLIC INHIBITION ON THE EXCITABILITY OF ISOLATED HIPPOCAMPAL CA1 NEURONS - DEVELOPMENTAL ASPECTS [J].
CUMMINS, TR ;
DONNELLY, DF ;
HADDAD, GG .
JOURNAL OF NEUROPHYSIOLOGY, 1991, 66 (05) :1471-1482
[8]   REVERSIBLE CHROMOSOME CONDENSATION INDUCED IN DROSOPHILA EMBRYOS BY ANOXIA - VISUALIZATION OF INTERPHASE NUCLEAR-ORGANIZATION [J].
FOE, VE ;
ALBERTS, BM .
JOURNAL OF CELL BIOLOGY, 1985, 100 (05) :1623-1636
[9]  
FRIEDMAN JE, 1993, J NEUROSCI, V13, P63
[10]   Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [J].
Graeber, TG ;
Osmanian, C ;
Jacks, T ;
Housman, DE ;
Koch, CJ ;
Lowe, SW ;
Giaccia, AJ .
NATURE, 1996, 379 (6560) :88-91