Cytosine-gated hole creation and transfer in DNA in aqueous solution

被引：32

作者：

Anderson, Robert F. ^{[1
]}

Shinde, Sujata S. ^{[1
]}

Maroz, Andrej ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland 1, New Zealand

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 50期

关键词：

DISTANCE CHARGE-TRANSPORT; FLASH-QUENCH TECHNIQUE; ELECTRON-TRANSFER; IONIZATION-POTENTIALS; HOPPING MECHANISM; PULSE-RADIOLYSIS; OXIDATIVE DAMAGE; STRAND BREAKAGE; PROTON-TRANSFER; BASE RADICALS;

D O I：

10.1021/ja0658416

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The selenite radical, SeO3-, has been found to selectively produce the cytosyl radical upon one-electron oxidation of duplex DNA. This is at first a surprising result as SeO3- can only oxidize guanine of the DNA bases, implying that the transiently formed guanyl radical cation must transpose into the neutral cytosyl radical with loss of a proton. Back oxidation to produce the neutral guanyl radical, in competition with another fixation reaction, is observed. Copyright © 2006 American Chemical Society.

引用

页码：15966 / 15967

页数：2

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