Radiation-induced apoptosis

被引：244

作者：

Verheij, M ^{[1
]}

Bartelink, H ^{[1
]}

机构：

[1] Netherlands Canc Inst, Antoni Van Leeuwenhoek Ziekenhuis, Dept Radiat Oncol, NL-1066 CX Amsterdam, Netherlands

来源：

CELL AND TISSUE RESEARCH | 2000年 / 301卷 / 01期

关键词：

ionizing radiation; clonogenic survival; apoptosis; signal transduction; p53; SAPK/JNK; caspases;

D O I：

10.1007/s004410000188

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Radiation-induced apoptosis has been a topic of intense research during the last decade. Its recognition as a significant component of radiation-induced cell death has initiated several lines of investigation aimed at modulating the apoptotic response and thereby radiosensitivity. These strategies require the integration of both classical radiobiological concepts and the knowledge of the biochemical and molecular biological mechanisms involved in apoptosis induction. This review discusses mechanisms of radiation-induced apoptosis and highlights the radiobiological and radiotherapeutical relevance of this mode of cell death.

引用

页码：133 / 142

页数：10

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