Irritable bowel syndrome: towards biomarker identification

被引:140
作者
Clarke, Gerard [1 ,2 ]
Quigley, Eamonn M. M. [1 ,3 ]
Cryan, John F. [1 ,4 ,5 ]
Dinan, Timothy G. [1 ,2 ]
机构
[1] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland
[2] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland
[3] Natl Univ Ireland Univ Coll Cork, Dept Med, Cork, Ireland
[4] Natl Univ Ireland Univ Coll Cork, Dept Pharmacol & Therapeut, Cork, Ireland
[5] Natl Univ Ireland Univ Coll Cork, Sch Pharm, Cork, Ireland
关键词
FUNCTIONAL GASTROINTESTINAL DISORDERS; SERINE-PROTEASE ACTIVITY; VISCERAL PAIN; COLORECTAL DISTENSION; MATERNAL SEPARATION; NEUROENDOCRINE RESPONSES; SEROTONIN TRANSPORTER; IMMUNE ACTIVATION; FECAL MICROBIOTA; CELL-ACTIVATION;
D O I
10.1016/j.molmed.2009.08.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder referred to gastroenterologists, affects 7-10% of the general population worldwide. The lack of suitable disease-defining biological markers coupled with a poorly understood underlying pathophysiology complicates patient diagnosis and seriously hampers drug discovery efforts. Over the past few years, a number of potential biomarkers have emerged, and in this review we critically evaluate such candidates. In particular, we highlight the increasing number of studies supporting a low-grade immune activation in IBS and consider how the latest preclinical developments can contribute to the development of more robust and reliable biological markers of this disorder. The successful identification of biomarkers is critical to progressing our understanding of IBS and addressing the unmet therapeutic needs of this debilitating condition.
引用
收藏
页码:478 / 489
页数:12
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