Michael reactions in water using Lewis acid-surfactant-combined catalysts

被引：121

作者：

Mori, Y ^{[1
]}

Kakumoto, K ^{[1
]}

Manabe, K ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Japan Sci & Technol Corp, CREST,Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 17期

基金：

日本学术振兴会;

关键词：

Michael reactions; surfactants; micellar systems; scandium and compounds; aqueous reactions;

D O I：

10.1016/S0040-4039(00)00319-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Michael reactions in water using Lewis acid-surfactant-combined catalysts (LASCs) have been developed. In the presence of a catalytic amount of scandium tris(dodecyl sulfate) (STDS), reactions of various beta-ketoesters with enones proceeded smoothly in water without any organic solvents, to afford the corresponding Michael adducts in high yields. The catalytic activity in water was found to be higher than that in organic solvents. Among the Lewis acids tested, STDS was proved to be the most superior Lewis acid catalyst for Michael reactions in water. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3107 / 3111

页数：5

共 15 条

[1]

Bergmann E.D., 1959, ORG REACTIONS, V10, P179

[2]

Christoffers J, 1998, EUR J ORG CHEM, V1998, P1259

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