Novel surface coatings modulating eukaryotic cell adhesion and preventing implant infection

被引：41

作者：

Groll, Juergen ^{[2
,3
]}

Fiedler, Joerg ^{[1
]}

Bruellhoff, Kristina ^{[2
,3
]}

Moeller, Martin ^{[2
,3
]}

Brenner, Rolf E. ^{[1
]}

机构：

[1] Univ Ulm, Dept Orthoped, Div Biochem Joint & Connect Tissue Dis, D-89081 Ulm, Germany

[2] Rhein Westfal TH Aachen, DWI EV, Aachen, Germany

[3] Rhein Westfal TH Aachen, Inst Tech & Macromol Chem, Aachen, Germany

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2009年 / 32卷 / 09期

关键词：

Implant coating; PEO; Star-polymer; Protein adsorption; Cell adhesion; Biofilm formation; SMALL-COLONY VARIANTS; BACTERIAL ADHESION; POLY(ETHYLENE GLYCOL); ULTRATHIN COATINGS; PROTEIN ADSORPTION; CHAIN DENSITY; PEG; INHIBITION; TITANIUM; STRAINS;

D O I：

10.1177/039139880903200915

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Poor osseointegration and bacterial infection are major causes of orthopedic implant failure. Both problems arise from passive unspecific protein coating that may not optimally support adhesion of osteoblastic cells and which enable bacterial adhesion that subsequently results in biofilm formation. This review addresses emerging concepts of preventing unspecific protein adsorption and biofilm formation by organic coating systems. We especially focus on recent concepts that additionally allow functionalization for preferential cell adhesion using cell adhesion mediating small peptide sequences that do not induce bacterial adherence. One promising approach that is presented and discussed within this context is the use of NCO-sP(EO-stat-PO). (Int J Artif Organs 2009; 32: 655-62)

引用

页码：655 / 662

页数：8

共 42 条

[1] Bacterial communications in implant infections: A target for an intelligence war [J].

Costerton, Jw ;

Montanaro, L. ;

Arciola, C. R. .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2007, 30 (09) :757-763

[2] Bacterial biofilms: A common cause of persistent infections [J].

Costerton, JW ;

Stewart, PS ;

Greenberg, EP .

SCIENCE, 1999, 284 (5418) :1318-1322

[3]

Dee KC, 1998, J BIOMED MATER RES, V40, P371, DOI 10.1002/(SICI)1097-4636(19980605)40:3<371::AID-JBM5>3.3.CO

[4]

2-G

[5] Bacterial adhesion: Seen any good biofilms lately? [J].

Dunne, WM .

CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (02) :155-+

[6] The inhibition of the adhesion of clinically isolated bacterial strains on multi-component cross-linked poly(ethylene glycol)-based polymer coatings [J].

Fernandez, Isabel C. Saldarriaga ;

van der Mei, Henny C. ;

Lochhead, Michael J. ;

Grainger, David W. ;

Busscher, Henk J. .

BIOMATERIALS, 2007, 28 (28) :4105-4112

[7] Antibacterial action of structurally diverse cationic peptides on gram-positive bacteria [J].

Friedrich, CL ;

Moyles, D ;

Beveridge, TJ ;

Hancock, REW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) :2086-2092

[8] Surface grafting of PEO-Based star-shaped molecules for bioanalytical and biomedical applications [J].

Gasteier, Peter ;

Reska, Anna ;

Schulte, Petra ;

Salber, Jochen ;

Offenhaeusser, Andreas ;

Moeller, Martin ;

Groll, Juergen .

MACROMOLECULAR BIOSCIENCE, 2007, 7 (08) :1010-1023

[9] The infected implant: Bacteriology [J].

Geipel, U ;

Herrmann, M .

UNFALLCHIRURG, 2005, 108 (11) :961-975

[10] Antimicrobial effects of positively charged surfaces on adhering Gram-positive and Gram-negative bacteria [J].

Gottenbos, B ;

Grijpma, DW ;

van der Mei, HC ;

Feijen, J ;

Busscher, HJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (01) :7-13

← 1 2 3 4 5 →