Macrophage inflammatory protein-1

被引：576

作者：

Menten, P ^{[1
]}

Wuyts, A ^{[1
]}

Van Damme, J ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Lab Mol Immunol, B-3000 Louvain, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2002年 / 13卷 / 06期

关键词：

LD78; induction; diseases; structure; receptors;

D O I：

10.1016/S1359-6101(02)00045-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophage inflammatory protein-1alpha (MIP-1alpha) and MIP-1beta are highly related members of the CC chemokine subfamily. Despite their structural similarities, MIP-1alpha and MIP-1beta show diverging signaling capacities. Depending on the MIP-1 subtype and its NH2-terminal processing, one or more of the CC chemokine receptors CCR1, CCR2, CCR3 and CCR5 are recognized. Since both human MIP-1alpha subtypes (LD78alpha and LD78beta) and MIP-1beta signal through CCR5, the major co-receptor for M-tropic HIV-1 strains, these chemokines are capable of inhibiting HIV-1 infection in susceptible cells. In this review, different aspects of human and mouse MIP-1alpha and MIP-1beta are discussed, including their protein and gene structures, their regulated production, their receptor usage and biological activities and their role in several pathologies including HIV-1 infection. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：455 / 481

页数：27

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